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Gene Review

sta  -  stubarista

Drosophila melanogaster

Synonyms: 37LRP/p40, 40S ribosomal protein SA, CG14792, Dmel\CG14792, EG:80H7.6, ...
 
 
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Disease relevance of sta

  • Genetic approaches using Drosophila and Caenorhabditis elegans have demonstrated a role for laminin and a laminin receptor in vivo in axon pathfinding and fasciculation, respectively [4,5] [1].
  • We have isolated and sequenced cDNA clones encoding two variants of the antigen and expressed one p40 clone in Escherichia coli [2].
 

High impact information on sta

  • Strikingly, the dramatic loss of acetylation of the K9 and K14 lysine residues of histone H3 in dGcn5 mutants has no noticeable effect on larval tissues [3].
  • Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs [4].
  • Indeed, silent substitutions in the orena lineage were significantly biased toward G and C at the consecutive yellow, lethal of scute, and asense loci, but they were significantly biased toward A and T at sta [5].
  • We provide genetic evidence that Dp(1;3)sta1 is mutant at the spineless (ss) locus and that it is associated with partial D-p40 activity [6].
  • Developmental analysis of the sta2 mutation implicates a requirement for D-p40 during oogenesis and imaginal development, which is consistent with the expression of sta throughout development [6].
 

Biological context of sta

  • Taking advantage of the existence of polytene chromosomes in the salivary glands of third instar larvae, we analyzed K9 and K14 H3 acetylation patterns in situ after UV irradiation of wild-type and Dmp53 null flies [7].
  • It is proposed that the VLP surface proteins p40 and p47.5 share antigenic determinants and significantly contribute to the strong virulence of their Hymenopteran hosts [8].
  • 5. Immuno-electron microscopy (EM) of the long gland-reservoir complex revealed that p40 was expressed early in VLP biogenesis and was detected along with VLP precursors within the long gland cells and lumen [8].
  • The antigen consists of a family of at least four near identical proteins, probably encoded by a multi-gene family, and expression of the p40 polypeptides is differentially regulated around the parasite's life cycle [2].
 

Analytical, diagnostic and therapeutic context of sta

  • Identification and immuno-electron microscopy localization of p40, a protein component of immunosuppressive virus-like particles from Leptopilina heterotoma, a virulent parasitoid wasp of Drosophila [8].

References

  1. Essential role of alpha 6 integrins in cortical and retinal lamination. Georges-Labouesse, E., Mark, M., Messaddeq, N., Gansmüller, A. Curr. Biol. (1998) [Pubmed]
  2. Sequence and expression of a major egg antigen from Schistosoma mansoni. Homologies to heat shock proteins and alpha-crystallins. Nene, V., Dunne, D.W., Johnson, K.S., Taylor, D.W., Cordingley, J.S. Mol. Biochem. Parasitol. (1986) [Pubmed]
  3. The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis. Carré, C., Szymczak, D., Pidoux, J., Antoniewski, C. Mol. Cell. Biol. (2005) [Pubmed]
  4. Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs. Török, I., Herrmann-Horle, D., Kiss, I., Tick, G., Speer, G., Schmitt, R., Mechler, B.M. Mol. Cell. Biol. (1999) [Pubmed]
  5. Local changes in GC/AT substitution biases and in crossover frequencies on Drosophila chromosomes. Takano-Shimizu, T. Mol. Biol. Evol. (2001) [Pubmed]
  6. The Drosophila stubarista phenotype is associated with a dosage effect of the putative ribosome-associated protein D-p40 on spineless. Melnick, M.B., Noll, E., Perrimon, N. Genetics (1993) [Pubmed]
  7. Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. Rebollar, E., Valadez-Graham, V., Vázquez, M., Reynaud, E., Zurita, M. FEBS Lett. (2006) [Pubmed]
  8. Identification and immuno-electron microscopy localization of p40, a protein component of immunosuppressive virus-like particles from Leptopilina heterotoma, a virulent parasitoid wasp of Drosophila. Chiu, H., Morales, J., Govind, S. J. Gen. Virol. (2006) [Pubmed]
 
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