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Gene Review:

MPS3 - Mps3p

Saccharomyces cerevisiae S288c

Synonyms: 98 kDa nuclear envelope protein, J1310, J1315, Monopolar spindle protein 3, NEP98, ...

Antoniacci, L.M. et al., Jaspersen, S.L. et al., Nishikawa, S. et al., Jaspersen, S.L. et al.

Jaspersen, Martin, Glazko, Giddings, Morgan, Mushegian, Winey,

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High impact information on MPS3

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope [1].
One SPB assembly mutant contained a mutation in a previously uncharacterized open reading frame that we call MPS3 (for monopolar spindle). mps3-1 mutants arrest in mitosis with monopolar spindles at the nonpermissive temperature, suggesting a defect in SPB duplication [2].
An in vivo cohesion assay on new mps3/nep98 alleles revealed that loss of Mps3p results in precocious sister chromatid separation and that Mps3p functions after G1, coincident with Ctf7p [3].
The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion [3].
Key steps in spindle pole body duplication are the sequential recruitment of Cdc31p and Spc42p by the nuclear envelope transmembrane protein Msp3p/Nep98p (herein termed Mps3p) [3].

Biological context of MPS3

Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion [4].

Anatomical context of MPS3

Here, we provide the first evidence that the nuclear envelope spindle pole body assembly component Mps3p performs a function critical to sister chromatid cohesion [3].
Nep98p is an essential integral membrane protein of the nuclear envelope and is enriched in the spindle pole body (SPB), the sole microtubule-organizing center in yeast [4].

References

The Sad1-UNC-84 homology domain in Mps3 interacts with Mps2 to connect the spindle pole body with the nuclear envelope. Jaspersen, S.L., Martin, A.E., Glazko, G., Giddings, T.H., Morgan, G., Mushegian, A., Winey, M. J. Cell Biol. (2006) [Pubmed]
Mps3p is a novel component of the yeast spindle pole body that interacts with the yeast centrin homologue Cdc31p. Jaspersen, S.L., Giddings, T.H., Winey, M. J. Cell Biol. (2002) [Pubmed]
The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion. Antoniacci, L.M., Kenna, M.A., Uetz, P., Fields, S., Skibbens, R.V. J. Biol. Chem. (2004) [Pubmed]
Nep98p is a component of the yeast spindle pole body and essential for nuclear division and fusion. Nishikawa, S., Terazawa, Y., Nakayama, T., Hirata, A., Makio, T., Endo, T. J. Biol. Chem. (2003) [Pubmed]

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AGOS_AGR312W	Ashbya gossypii ATCC 10895
KLLA0F22539g	Kluyveromyces lactis NRRL Y-1140

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