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Gene Review

ECO1  -  Eco1p

Saccharomyces cerevisiae S288c

Synonyms: CTF7, Chromosome transmission fidelity protein 7, Establishment of cohesion protein 1, N-acetyltransferase ECO1, YFR027W
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High impact information on ECO1


Biological context of ECO1


Associations of ECO1 with chemical compounds

  • We found a two-domain architecture with an N-terminal C2H2 Zn finger-like domain and an approximately 150 residue C-terminal domain with an apparent acetyl coenzyme A binding motif ( [7].
  • Interestingly, in the fission yeast Schizosaccharomyces pombe, the eso1(+) encoded protein is comprised of two domains, wherein the NH(2) terminus is highly homologous to Poleta, and the COOH terminus is highly homologous to the S. cerevisiae Ctf7 protein which is essential for the establishment of sister chromatid cohesion during S phase [9].
  • In this report, we identify and characterize the first candidate human ortholog of Ctf7p/Eco1p, which we term hEFO1p (human Establishment Factor Ortholog) [10].

Other interactions of ECO1


Analytical, diagnostic and therapeutic context of ECO1

  • Mps3p was identified as interacting with Ctf7p from a genome-wide two-hybrid screen, and the physical interaction was confirmed by both in vivo (co-immunoprecipitation) and in vitro (GST pull-down) assays [6].


  1. Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery. Skibbens, R.V., Corson, L.B., Koshland, D., Hieter, P. Genes Dev. (1999) [Pubmed]
  2. PCNA controls establishment of sister chromatid cohesion during S phase. Moldovan, G.L., Pfander, B., Jentsch, S. Mol. Cell (2006) [Pubmed]
  3. Transcriptional activation by CTF proteins is mediated by a bipartite low-proline domain. Altmann, H., Wendler, W., Winnacker, E.L. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Mechanical link between cohesion establishment and DNA replication: Ctf7p/Eco1p, a cohesion establishment factor, associates with three different replication factor C complexes. Kenna, M.A., Skibbens, R.V. Mol. Cell. Biol. (2003) [Pubmed]
  5. Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Skibbens, R.V. Genetics (2004) [Pubmed]
  6. The spindle pole body assembly component mps3p/nep98p functions in sister chromatid cohesion. Antoniacci, L.M., Kenna, M.A., Uetz, P., Fields, S., Skibbens, R.V. J. Biol. Chem. (2004) [Pubmed]
  7. Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Ivanov, D., Schleiffer, A., Eisenhaber, F., Mechtler, K., Haering, C.H., Nasmyth, K. Curr. Biol. (2002) [Pubmed]
  8. Sister-chromatid telomere cohesion is nonredundant and resists both spindle forces and telomere motility. Antoniacci, L.M., Skibbens, R.V. Curr. Biol. (2006) [Pubmed]
  9. Fidelity and damage bypass ability of Schizosaccharomyces pombe Eso1 protein, comprised of DNA polymerase eta and sister chromatid cohesion protein Ctf7. Madril, A.C., Johnson, R.E., Washington, M.T., Prakash, L., Prakash, S. J. Biol. Chem. (2001) [Pubmed]
  10. Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains. Bellows, A.M., Kenna, M.A., Cassimeris, L., Skibbens, R.V. Nucleic Acids Res. (2003) [Pubmed]
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