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Gene Review:

TES1 - Tes1p

Saccharomyces cerevisiae S288c

Synonyms: J1456, PTE1, Peroxisomal acyl-coenzyme A thioester hydrolase 1, Peroxisomal long-chain acyl-CoA thioesterase 1, YJR019C

Jones, J.M. et al., Maeda, I. et al.

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High impact information on TES1

A purified histidine-tagged Pte1p showed high activity toward short and medium chain length acyl-CoAs, including butyryl-CoA, decanoyl-CoA and 8-methyl-nonanoyl-CoA [1].
A computer-based screen of the Saccharomyces cerevisiae genome identified YJR019C as a candidate oleate-induced gene [2].
YJR019C directed green fluorescence protein to peroxisomes, and biochemical studies revealed that YJR019C is an abundant component of purified yeast peroxisomes [2].
The YJR019C product is highly similar to tesB, a bacterial acyl-CoA thioesterase, and carries a tripeptide sequence, alanine-lysine-phenylalanineCOOH, that closely resembles the consensus sequence for type-1 peroxisomal targeting signals [2].

References

The Peroxisomal Acyl-CoA Thioesterase Pte1p from Saccharomyces cerevisiae Is Required for Efficient Degradation of Short Straight Chain and Branched Chain Fatty Acids. Maeda, I., Delessert, S., Hasegawa, S., Seto, Y., Zuber, S., Poirier, Y. J. Biol. Chem. (2006) [Pubmed]
Identification of peroxisomal acyl-CoA thioesterases in yeast and humans. Jones, J.M., Nau, K., Geraghty, M.T., Erdmann, R., Gould, S.J. J. Biol. Chem. (1999) [Pubmed]

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