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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

YMR1  -  phosphatidylinositol-3-phosphatase YMR1

Saccharomyces cerevisiae S288c

Synonyms: J2007, Phosphoinositide 3-phosphatase, YJR110W, Yeast myotubularin-related protein 1
 
 
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High impact information on YMR1

  • Triple deletion of YMR1, SJL2, and SJL3 was lethal, suggesting an essential requirement for phosphatase-mediated PI(3)P regulation [1].
  • We conducted a genetic screen to isolate genes that, when overexpressed, would rescue the conditional lethality of ymr1Delta sjl2Delta sjl3Delta triple-mutant cells expressing YMR1 from the dextrose-repressible GAL1 promoter [2].
  • Taken together, the results of this study indicated that aberrant Rho1p/Pkc1p signaling contributes to the lethal effects of PtdIns(3)P accumulation in cells deficient in PI 3-phosphatase activity [2].
 

Associations of YMR1 with chemical compounds

References

  1. Essential role for the myotubularin-related phosphatase Ymr1p and the synaptojanin-like phosphatases Sjl2p and Sjl3p in regulation of phosphatidylinositol 3-phosphate in yeast. Parrish, W.R., Stefan, C.J., Emr, S.D. Mol. Biol. Cell (2004) [Pubmed]
  2. PtdIns(3)P accumulation in triple lipid-phosphatase-deletion mutants triggers lethal hyperactivation of the Rho1p/Pkc1p cell-integrity MAP kinase pathway. Parrish, W.R., Stefan, C.J., Emr, S.D. J. Cell. Sci. (2005) [Pubmed]
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