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Gene Review

YMR1  -  phosphatidylinositol-3-phosphatase YMR1

Saccharomyces cerevisiae S288c

Synonyms: J2007, Phosphoinositide 3-phosphatase, YJR110W, Yeast myotubularin-related protein 1
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High impact information on YMR1

  • Triple deletion of YMR1, SJL2, and SJL3 was lethal, suggesting an essential requirement for phosphatase-mediated PI(3)P regulation [1].
  • We conducted a genetic screen to isolate genes that, when overexpressed, would rescue the conditional lethality of ymr1Delta sjl2Delta sjl3Delta triple-mutant cells expressing YMR1 from the dextrose-repressible GAL1 promoter [2].
  • Taken together, the results of this study indicated that aberrant Rho1p/Pkc1p signaling contributes to the lethal effects of PtdIns(3)P accumulation in cells deficient in PI 3-phosphatase activity [2].

Associations of YMR1 with chemical compounds


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