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Gene Review

MTMR6  -  myotubularin related protein 6

Homo sapiens

Synonyms: Myotubularin-related protein 6
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High impact information on MTMR6

  • Moreover, by inhibiting KCa3.1, MTMR6 functions as a negative regulator of Ca2+ influx and proliferation of reactivated human CD4 T cells [1].
  • Some of these genes encode general apoptotic factors but also exhibit lymphoid cell specificities that could potentially be linked to the development of lymphoid malignancies (MIP1alpha, blk, TR3, mtmr6) [2].
  • We recently found that the KCa3.1 channel also specifically requires phosphatidylinositol-3 phosphate [PI(3)P] for channel activity and is inhibited by myotubularin-related protein 6 (MTMR6), a PI(3)P phosphatase [3].
  • Immunofluorescent microscopy demonstrated that both the MTMR6 CC and PH/G domains are required to co-localize MTMR6 to the plasma membrane with KCa3 [4].
  • We have investigated MTM1 and MTMR6 and find that they use PtdIns(3,5)P2 in addition to PtdIns3P as a substrate in vitro [5].

Other interactions of MTMR6

  • We recently found that MTMR6 specifically inhibits the Ca(2+)-activated K(+) channel, KCa3.1, by dephosphorylating PI(3)P [4].


  1. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Srivastava, S., Ko, K., Choudhury, P., Li, Z., Johnson, A.K., Nadkarni, V., Unutmaz, D., Coetzee, W.A., Skolnik, E.Y. Mol. Cell. Biol. (2006) [Pubmed]
  2. The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays. Vallat, L., Magdelénat, H., Merle-Béral, H., Masdehors, P., Potocki de Montalk, G., Davi, F., Kruhoffer, M., Sabatier, L., Orntoft, T.F., Delic, J. Blood (2003) [Pubmed]
  3. Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. Srivastava, S., Choudhury, P., Li, Z., Liu, G., Nadkarni, V., Ko, K., Coetzee, W.A., Skolnik, E.Y. Mol. Biol. Cell (2006) [Pubmed]
  4. Specificity of the Myotubularin Family of Phosphatidylinositol-3-phosphatase Is Determined by the PH/GRAM Domain. Choudhury, P., Srivastava, S., Li, Z., Ko, K., Albaqumi, M., Narayan, K., Coetzee, W.A., Lemmon, M.A., Skolnik, E.Y. J. Biol. Chem. (2006) [Pubmed]
  5. Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases. Schaletzky, J., Dove, S.K., Short, B., Lorenzo, O., Clague, M.J., Barr, F.A. Curr. Biol. (2003) [Pubmed]
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