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Gene Review:

ACP1 - Acp1p

Saccharomyces cerevisiae S288c

Synonyms: ACP, Acyl carrier protein, mitochondrial, NADH-ubiquinone oxidoreductase 9.6 kDa subunit, YKL192C

Brody, S. et al., Schneider, R. et al.

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High impact information on ACP1

The role of ACP1 in long-chain fatty acid synthesis was studied in fast and fas2 null mutants completely lacking cytoplasmic fatty acid synthase [1].
Upon meiosis, the lipoate deficiency co-segregated with the acp1 deletion [1].
The resulting acp1-deficient mutants had only 5-10% of the wild-type lipoic acid content remaining, and exhibited a respiratory-deficient phenotype [1].
Mitochondrial ACP is therefore suggested to be involved with the biosynthesis of octanoate, a precursor to lipoic acid [1].

Biological context of ACP1

In S. cerevisiae, the loss of ACP1 leads to a pleiotropic respiratory deficient phenotype [2].

References

Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae. Brody, S., Oh, C., Hoja, U., Schweizer, E. FEBS Lett. (1997) [Pubmed]
Different respiratory-defective phenotypes of Neurospora crassa and Saccharomyces cerevisiae after inactivation of the gene encoding the mitochondrial acyl carrier protein. Schneider, R., Massow, M., Lisowsky, T., Weiss, H. Curr. Genet. (1995) [Pubmed]

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mtACP2	Arabidopsis thaliana
AGOS_AER103W	Ashbya gossypii ATCC 10895
KLLA0D02838g	Kluyveromyces lactis NRRL Y-1140
MGG_03484	Magnaporthe oryzae 70-15
NCU05008	Neurospora crassa OR74A
Os03g0352800	Oryza sativa Japonica Group
SPAC4H3.09	Schizosaccharomyces pombe 972h-

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