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Chemical Compound Review

octylate     octanoic acid

Synonyms: capryloate, Octansaeure, Caprylsaeure, Kaprylsaeure, n-octoate, ...
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Disease relevance of octanoic acid


Psychiatry related information on octanoic acid


High impact information on octanoic acid


Chemical compound and disease context of octanoic acid


Biological context of octanoic acid


Anatomical context of octanoic acid


Associations of octanoic acid with other chemical compounds


Gene context of octanoic acid


Analytical, diagnostic and therapeutic context of octanoic acid

  • 14C can be replaced by 13C for labeling the octanoic acid used in the breath test [12].
  • Biological assays revealed that retention of activity was inversely dependent both on the number of chains introduced and on their length; activity was most conserved (greater than 50%) in a TNF preparation modified with only approximately 1-2.5 caprylic acid (C8) residues/trimer [36].
  • For octanoic acid bound to BSA (6:1, mol/mol), the chemical shift of the only FA carboxyl resonance (designated as peak c), plotted as a function of pH, exhibited a complete sigmoidal titration curve that deviated in shape from a corresponding theoretical Henderson-Hasselbach curve [37].
  • Intrahepatic implants of M114 carcinoma in B6D2F1/J mice were treated by intraperitoneal injection of 30 mg sodium caprylate (octanoate), and implants of Nb2 lymphoma in Nb rats were treated with 300 mg tricaprylin orally [38].
  • Effects of octanoic acid on monoamines and their acidic metabolites in the rat brain were analyzed by HPLC [39].


  1. Dietary modification of chyle composition in chylothorax. Jensen, G.L., Mascioli, E.A., Meyer, L.P., Lopes, S.M., Bell, S.J., Babayan, V.K., Blackburn, G.L., Bistrian, B.R. Gastroenterology (1989) [Pubmed]
  2. The Mycobacterium tuberculosis LipB enzyme functions as a cysteine/lysine dyad acyltransferase. Ma, Q., Zhao, X., Eddine, A.N., Geerlof, A., Li, X., Cronan, J.E., Kaufmann, S.H., Wilmanns, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. Mundlos, S., Kühnelt, P., Adler, G. Gut (1990) [Pubmed]
  4. Short chain fatty acid-induced central hyperventilation in rabbits. Trauner, D.A., Huttenlocher, P.R. Neurology (1978) [Pubmed]
  5. Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Zhao, X., Miller, J.R., Jiang, Y., Marletta, M.A., Cronan, J.E. Chem. Biol. (2003) [Pubmed]
  6. Regulation of food intake by acyl and des-acyl ghrelins in the goldfish. Matsuda, K., Miura, T., Kaiya, H., Maruyama, K., Shimakura, S., Uchiyama, M., Kangawa, K., Shioda, S. Peptides (2006) [Pubmed]
  7. Synthesis of structured phospholipids by immobilized phospholipase A(2) catalyzed acidolysis. Vikbjerg, A.F., Mu, H., Xu, X. J. Biotechnol. (2007) [Pubmed]
  8. Satiety from fat? Adverse effects of intestinal infusion of sodium oleate. Ramirez, I., Tordoff, M.G., Friedman, M.I. Am. J. Physiol. (1997) [Pubmed]
  9. Peroxisomal beta-oxidation of fatty acids in bovine and rat liver. Grum, D.E., Hansen, L.R., Drackley, J.K. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1994) [Pubmed]
  10. Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. Sidossis, L.S., Stuart, C.A., Shulman, G.I., Lopaschuk, G.D., Wolfe, R.R. J. Clin. Invest. (1996) [Pubmed]
  11. Enhanced lymphocyte interaction in postcapillary venules of Peyer's patches during fat absorption in rats. Tsuzuki, Y., Miura, S., Kurose, I., Suematsu, M., Higuchi, H., Shigematsu, T., Kimura, H., Serizawa, H., Hokari, R., Akiba, Y., Yagita, H., Okumura, K., Tso, P., Granger, D.N., Ishii, H. Gastroenterology (1997) [Pubmed]
  12. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Ghoos, Y.F., Maes, B.D., Geypens, B.J., Mys, G., Hiele, M.I., Rutgeerts, P.J., Vantrappen, G. Gastroenterology (1993) [Pubmed]
  13. Multiple abnormalities in insulin responses to nonglucose nutrients in neonatally streptozotocin diabetic rats. Grill, V., Sako, Y., Ostenson, C.G., Jalkanen, P. Endocrinology (1991) [Pubmed]
  14. Cis-4-decenoic acid in plasma: a characteristic metabolite in medium-chain acyl-CoA dehydrogenase deficiency. Duran, M., Bruinvis, L., Ketting, D., de Klerk, J.B., Wadman, S.K. Clin. Chem. (1988) [Pubmed]
  15. Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats. Leclercq, P., Filippi, C., Sibille, B., Hamant, S., Keriel, C., Leverve, X.M. Biochem. J. (1997) [Pubmed]
  16. Biosynthesis of lipoic acid: characterization of the lipoic acid auxotrophs Escherichia coli W1485-lip2 and JRG33-lip9. Hayden, M.A., Huang, I.Y., Iliopoulos, G., Orozco, M., Ashley, G.W. Biochemistry (1993) [Pubmed]
  17. The cholesteryl octanoate breath test: a new procedure for detection of pancreatic insufficiency in the rat. Mundlos, S., Rhodes, J.B., Hofmann, A.F. Pediatr. Res. (1987) [Pubmed]
  18. Cholesteryl octanoate breath test. Preliminary studies on a new noninvasive test of human pancreatic exocrine function. Cole, S.G., Rossi, S., Stern, A., Hofmann, A.F. Gastroenterology (1987) [Pubmed]
  19. Rates of gluconeogenesis and citric acid cycle in perfused livers, assessed from the mass spectrometric assay of the 13C labeling pattern of glutamate. Di Donato, L., Des Rosiers, C., Montgomery, J.A., David, F., Garneau, M., Brunengraber, H. J. Biol. Chem. (1993) [Pubmed]
  20. Competitive binding of long-chain free fatty acids, octanoate, and chlorophenoxyisobutyrate to albumin. Meisner, H., Neet, K. Mol. Pharmacol. (1978) [Pubmed]
  21. Effects of glucose starvation on the oxidation of fatty acids by maize root tip mitochondria and peroxisomes: evidence for mitochondrial fatty acid beta-oxidation and acyl-CoA dehydrogenase activity in a higher plant. Dieuaide, M., Couée, I., Pradet, A., Raymond, P. Biochem. J. (1993) [Pubmed]
  22. Influence of mixtures of taurocholate, fatty acids, and monolein on the toxic effects of deoxycholate in rat jejunum in vivo. Lamabadusuriya, S.P., Guiraldes, E., Harries, J.T. Gastroenterology (1975) [Pubmed]
  23. Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers. Hamilton, J.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  24. Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation. Asaoka, Y., Oka, M., Yoshida, K., Nishizuka, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  25. Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. Kawaguchi, T., Osatomi, K., Yamashita, H., Kabashima, T., Uyeda, K. J. Biol. Chem. (2002) [Pubmed]
  26. Beta-adrenergic modulation of Ca2+ uptake by isolated brown adipocytes. Possible involvement of mitochondria. Connolly, E., Nedergaard, J. J. Biol. Chem. (1988) [Pubmed]
  27. Ammonia, octanoate and a mercaptan depress regeneration of normal rat liver after partial hepatectomy. Zieve, L., Shekleton, M., Lyftogt, C., Draves, K. Hepatology (1985) [Pubmed]
  28. Regulation of hepatic gluconeogenesis in the guinea pig by fatty acids and ammonia. Jomain-Baum, M., Hanson, R.W. J. Biol. Chem. (1975) [Pubmed]
  29. Quantitation of the effect of L-carnitine on the levels of acid-soluble short-chain acyl-CoA and CoASH in rat heart and liver mitochondria. Lysiak, W., Lilly, K., DiLisa, F., Toth, P.P., Bieber, L.L. J. Biol. Chem. (1988) [Pubmed]
  30. Hexanoate and octanoate inhibit transcription of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture. Roncero, C., Goodridge, A.G. J. Biol. Chem. (1992) [Pubmed]
  31. Mechanism of increased conversion of branched chain keto acid dehydrogenase from inactive to active form by a medium chain fatty acid (octanoate) in skeletal muscle. Paul, H.S., Adibi, S.A. J. Biol. Chem. (1992) [Pubmed]
  32. Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. Viegas, C.A., Supply, P., Capieaux, E., Van Dyck, L., Goffeau, A., Sá-Correia, I. Biochim. Biophys. Acta (1994) [Pubmed]
  33. Biological, physiological, and pharmacological aspects of ghrelin. Hosoda, H., Kojima, M., Kangawa, K. J. Pharmacol. Sci. (2006) [Pubmed]
  34. Octanoate reduces very low-density lipoprotein secretion by decreasing the synthesis of apolipoprotein B in primary cultures of chicken hepatocytes. Tachibana, S., Sato, K., Cho, Y., Chiba, T., Schneider, W.J., Akiba, Y. Biochim. Biophys. Acta (2005) [Pubmed]
  35. Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids. Irie, H., Krukenkamp, I.B., Brinkmann, J.F., Gaudette, G.R., Saltman, A.E., Jou, W., Glatz, J.F., Abumrad, N.A., Ibrahimi, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  36. Preparation and characterization of liposomal-lipophilic tumor necrosis factor. Utsumi, T., Hung, M.C., Klostergaard, J. Cancer Res. (1991) [Pubmed]
  37. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. Cistola, D.P., Small, D.M., Hamilton, J.A. J. Biol. Chem. (1987) [Pubmed]
  38. Oncolytic effects of fatty acids in mice and rats. Burton, A.F. Am. J. Clin. Nutr. (1991) [Pubmed]
  39. Octanoic acid produces accumulation of monoamine acidic metabolites in the brain: interaction with organic anion transport at the choroid plexus. Kim, C.S., Roe, C.R., Mann, J.D., Breese, G.R. J. Neurochem. (1992) [Pubmed]
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