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Gene Review:

MTR2 - Mtr2p

Saccharomyces cerevisiae S288c

Synonyms: YKL186C, mRNA transport regulator MTR2

Strässer, K. et al., Kadowaki, T. et al., Strässer, K. et al., Nissan, T.A. et al., Strässer, K. et al., et al.

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Disease relevance of MTR2

MTR2 shows limited homology to a protein implicated in plasmid DNA transfer in Escherichia coli [1].

High impact information on MTR2

Yra1p interacts directly with the mRNA transport factor Mex67p/Mtr2p, which is associated with the nuclear pore [2].
When the 60S precursor particles are close to exit from the nucleus they associate with at least two export factors, Nmd3 and Mtr2 [3].
These data suggest a model in which nuclear mRNA export requires the Mex67p/Mtr2p heterodimeric complex to directly contact several repeat nucleoporins, organized in different nuclear pore complex subcomplexes, as it carries the mRNP cargo through the nuclear pore [4].
Thus, Yra1p is the first RNA-binding protein characterized, which bridges the shuttling Mex67p/Mtr2p exporter to intranuclear mRNA transport cargoes [5].
At the nuclear pores, Nup85p represents one of the targets with which the Mex67p-Mtr2p complex interacts [6].

Anatomical context of MTR2

It is not known how Mex67p and Mtr2p, which form a heterodimer essential for mRNA export, transport mRNPs through the nuclear pore [4].

Physical interactions of MTR2

Here, we show that the Mex67p/Mtr2p complex binds to all of the repeat types (GLFG, FXFG, and FG) found in nucleoporins [4].

Other interactions of MTR2

Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export [4].
Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant [1].

References

Nuclear mRNA accumulation causes nucleolar fragmentation in yeast mtr2 mutant. Kadowaki, T., Hitomi, M., Chen, S., Tartakoff, A.M. Mol. Biol. Cell (1994) [Pubmed]
Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Strässer, K., Hurt, E. Nature (2001) [Pubmed]
60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm. Nissan, T.A., Bassler, J., Petfalski, E., Tollervey, D., Hurt, E. EMBO J. (2002) [Pubmed]
Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export. Strässer, K., Bassler, J., Hurt, E. J. Cell Biol. (2000) [Pubmed]
Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export. Strässer, K., Hurt, E. EMBO J. (2000) [Pubmed]
Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores. Santos-Rosa, H., Moreno, H., Simos, G., Segref, A., Fahrenkrog, B., Panté, N., Hurt, E. Mol. Cell. Biol. (1998) [Pubmed]

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