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Gene Review

NUP85  -  Nup85p

Saccharomyces cerevisiae S288c

Synonyms: J1624, Nuclear pore protein NUP85, Nucleoporin NUP85, RAT9, YJR042W
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High impact information on NUP85


Anatomical context of NUP85

  • At the permissive growth temperature in rat9-1 or RAT9 deletion strains, the nuclear envelope (NE) becomes detached from the main body of the nucleus, forming long thin double sheets of NE [6].
  • In this study, a member of the yeast nuclear pore complex (Nup85p) was tagged and a six-member sub-complex of the pore was cross-linked and analyzed by 1D SDS-PAGE [7].

Physical interactions of NUP85

  • More interestingly, we demonstrate that the Nup84p complex contains Nup133p as a subunit and binds to the FG repeat regions of Nups directly via the Nup85p subunit [8].

Other interactions of NUP85


  1. A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores. Siniossoglou, S., Wimmer, C., Rieger, M., Doye, V., Tekotte, H., Weise, C., Emig, S., Segref, A., Hurt, E.C. Cell (1996) [Pubmed]
  2. Structure and assembly of the Nup84p complex. Siniossoglou, S., Lutzmann, M., Santos-Rosa, H., Leonard, K., Mueller, S., Aebi, U., Hurt, E. J. Cell Biol. (2000) [Pubmed]
  3. Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. Senger, B., Simos, G., Bischoff, F.R., Podtelejnikov, A., Mann, M., Hurt, E. EMBO J. (1998) [Pubmed]
  4. Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. Segref, A., Sharma, K., Doye, V., Hellwig, A., Huber, J., Lührmann, R., Hurt, E. EMBO J. (1997) [Pubmed]
  5. Yeast nucleoporin mutants are defective in pre-tRNA splicing. Sharma, K., Fabre, E., Tekotte, H., Hurt, E.C., Tollervey, D. Mol. Cell. Biol. (1996) [Pubmed]
  6. Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p. Goldstein, A.L., Snay, C.A., Heath, C.V., Cole, C.N. Mol. Biol. Cell (1996) [Pubmed]
  7. A generic strategy to analyze the spatial organization of multi-protein complexes by cross-linking and mass spectrometry. Rappsilber, J., Siniossoglou, S., Hurt, E.C., Mann, M. Anal. Chem. (2000) [Pubmed]
  8. Deciphering networks of protein interactions at the nuclear pore complex. Allen, N.P., Patel, S.S., Huang, L., Chalkley, R.J., Burlingame, A., Lutzmann, M., Hurt, E.C., Rexach, M. Mol. Cell Proteomics (2002) [Pubmed]
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