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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRT2  -  tRNA

Saccharomyces cerevisiae S288c

 
 
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High impact information on TRT2

  • In the cell cycle of the budding yeast Saccharomyces cerevisiae, expression of the histone genes H2A and H2B of the TRT1 and TRT2 loci is regulated by the performance of "start," the step that also regulates the cell cycle [1].
  • Deletion of TRT1, one of the H2A-H2B gene pair sets, affected mitotic growth, sporulation, spore germination, the heat shock response, and exit from the stationary phase; deletion of TRT2, the other H2A-H2B gene pair set, had negligible effects on these same processes [2].
  • The Saccharomyces cerevisiae TRT2 tRNAThr gene upstream of STE6 is a barrier to repression in MATalpha cells and exerts a potential tRNA position effect in MATa cells [3].
  • Interestingly, deletion of TRT2 results in an increase in CBT1 mRNA levels in MATa cells, indicating a potential tRNA position effect [3].

References

  1. Induction of yeast histone genes by stimulation of stationary-phase cells. Drebot, M.A., Veinot-Drebot, L.M., Singer, R.A., Johnston, G.C. Mol. Cell. Biol. (1990) [Pubmed]
  2. The two gene pairs encoding H2A and H2B play different roles in the Saccharomyces cerevisiae life cycle. Norris, D., Osley, M.A. Mol. Cell. Biol. (1987) [Pubmed]
  3. The Saccharomyces cerevisiae TRT2 tRNAThr gene upstream of STE6 is a barrier to repression in MATalpha cells and exerts a potential tRNA position effect in MATa cells. Simms, T.A., Miller, E.C., Buisson, N.P., Jambunathan, N., Donze, D. Nucleic Acids Res. (2004) [Pubmed]
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