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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CBT1  -  Cbt1p

Saccharomyces cerevisiae S288c

Synonyms: Cytochrome b termination protein 1, SOC1, YKL208W
 
 
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High impact information on CBT1

  • Cbt1p is also required for stabilizing the mature cytochrome b mRNA after 5' processing [1].
  • Screening of two S. cerevisiae cDNA libraries led to the identification of CBT1 as a gene which, if overexpressed simultaneously with CDC14, results in the rescue of the dbJ2-2 mutation at restrictive temperature on galactose-based medium, as well as on media containing non-fermentable carbon sources such as glycerol, lactate and acetate [2].
  • Dbf2 is implicated in a Cbt1-dependent pathway following a shift from glucose to galactose or non-fermentable carbon sources in Saccharomyces cerevisiae [2].
  • Interestingly, deletion of TRT2 results in an increase in CBT1 mRNA levels in MATa cells, indicating a potential tRNA position effect [3].
 

Anatomical context of CBT1

 

Other interactions of CBT1

  • Quantitative primer extension analysis indicated that cbt1 null strains have defects in 5'-end processing of precursor cytochrome b mRNA to the mature form [1].

References

  1. CBT1 interacts genetically with CBP1 and the mitochondrially encoded cytochrome b gene and is required to stabilize the mature cytochrome b mRNA of Saccharomyces cerevisiae. Ellis, T.P., Schonauer, M.S., Dieckmann, C.L. Genetics (2005) [Pubmed]
  2. Dbf2 is implicated in a Cbt1-dependent pathway following a shift from glucose to galactose or non-fermentable carbon sources in Saccharomyces cerevisiae. Grandin, N., Charbonneau, M. Mol. Gen. Genet. (1999) [Pubmed]
  3. The Saccharomyces cerevisiae TRT2 tRNAThr gene upstream of STE6 is a barrier to repression in MATalpha cells and exerts a potential tRNA position effect in MATa cells. Simms, T.A., Miller, E.C., Buisson, N.P., Jambunathan, N., Donze, D. Nucleic Acids Res. (2004) [Pubmed]
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