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Gene Review:

DCW1 - Dcw1p

Saccharomyces cerevisiae S288c

Synonyms: Defective cell wall 1, Endo-alpha-1->6-D-mannanase DCW1, Mannan endo-1,6-alpha-mannosidase DCW1, YKL046C, YKL259

Kitagaki, H. et al., Kitagaki, H. et al.

Kitagaki, Wu, Shimoi, Ito,

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High impact information on DCW1

Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)-anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae [1].
We therefore designated this gene as DCW1 (defective cell wall) [1].
To investigate the roles of these proteins in cell wall biogenesis and cell growth, we constructed mutant alleles of DCW1 by random mutagenesis, introduced them into a Deltadcw1 Deltadfg5 background, and isolated a temperature-sensitive mutant, DC61 (dcw1-3 Deltadfg5) [2].
A temperature-sensitive dcw1 mutant of Saccharomyces cerevisiae is cell cycle arrested with small buds which have aberrant cell walls [2].

Biological context of DCW1

DCW1 and DFG5 mRNA levels peaked in the G1 and S phases, respectively [2].
A double disruptant of dcw1 and dfg5 was synthetically lethal, indicating that the functions of these gene products are redundant, and at least one of them is required for cell growth [1].

References

Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)-anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae. Kitagaki, H., Wu, H., Shimoi, H., Ito, K. Mol. Microbiol. (2002) [Pubmed]
A temperature-sensitive dcw1 mutant of Saccharomyces cerevisiae is cell cycle arrested with small buds which have aberrant cell walls. Kitagaki, H., Ito, K., Shimoi, H. Eukaryotic Cell (2004) [Pubmed]

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AGOS_ABR060W	Ashbya gossypii ATCC 10895
KLLA0E07723g	Kluyveromyces lactis NRRL Y-1140
MGG_04015	Magnaporthe oryzae 70-15
NCU03770	Neurospora crassa OR74A
SPCC970.02	Schizosaccharomyces pombe 972h-

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