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Gene Review

PAN3  -  Pan3p

Saccharomyces cerevisiae S288c

Synonyms: ECM35, PAB-dependent poly(A)-specific ribonuclease subunit PAN3, PAB1P-dependent poly(A)-nuclease, PAN deadenylation complex subunit 3, YKL025C
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High impact information on PAN3

  • We also provide evidence that the Pan2p/Pan3p nuclease complex encodes the predominant alternative deadenylase [1].
  • The importance of these amino acids for Pab1p-Pan3p interaction, and poly(A) tail regulation, is underscored by experiments demonstrating that strains harboring substitutions in these residues accumulate mRNAs with long poly(A) tails in vivo [2].
  • Here we report that the Dun1 forkhead-associated domain interacts with the Pan3 subunit of the poly(A)-nuclease complex and that dun1pan2 and dun1pan3 double mutants are dramatically hypersensitive to replicational stress [3].

Biological context of PAN3


Other interactions of PAN3

  • In addition, we demonstrate that a deletion of PAN2, PAN3, or both resulted in similar increases in mRNA poly(A) tail lengths in vivo [5].
  • PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae [5].
  • However, the domains required for Pan3p and Pbp1p binding on Pab1p are distinct [2].


  1. The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Tucker, M., Valencia-Sanchez, M.A., Staples, R.R., Chen, J., Denis, C.L., Parker, R. Cell (2001) [Pubmed]
  2. Positive and negative regulation of poly(A) nuclease. Mangus, D.A., Evans, M.C., Agrin, N.S., Smith, M., Gongidi, P., Jacobson, A. Mol. Cell. Biol. (2004) [Pubmed]
  3. Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks. Hammet, A., Pike, B.L., Heierhorst, J. J. Biol. Chem. (2002) [Pubmed]
  4. Analysis of an essential requirement for the poly(A) binding protein function using cross-species complementation. Chekanova, J.A., Shaw, R.J., Belostotsky, D.A. Curr. Biol. (2001) [Pubmed]
  5. PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae. Brown, C.E., Tarun, S.Z., Boeck, R., Sachs, A.B. Mol. Cell. Biol. (1996) [Pubmed]
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