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Gene Review

PAN2  -  Pan2p

Saccharomyces cerevisiae S288c

Synonyms: PAB-dependent poly(A)-specific ribonuclease subunit PAN2, PAB1P-dependent poly(A)-nuclease, PAN deadenylation complex catalytic subunit 2, YGL094C
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Disease relevance of PAN2

  • We examined the effects of deletions of genes encoding deadenylase components Ccr4p and Pan2p and putative RNA-binding proteins Pub1p and Puf4p on the genome-wide pattern of mRNA stability after inhibition of transcription by chemicals and/or heat stress [1].

High impact information on PAN2

  • The strong conservation of Ccr4p, Caf1p, Pan2p, and Pan3p indicates that they will function as deadenylases in other eukaryotes [2].
  • We also provide evidence that the Pan2p/Pan3p nuclease complex encodes the predominant alternative deadenylase [2].
  • In contrast to two other DEDD family members, PAN2 and PARN, mCAF1 was not activated either by PAB1 or capped RNA substrates [3].
  • The data indicate that Dun1 and Pan2-Pan3 cooperate to regulate the stoichiometry and thereby the activity of postreplication repair complexes, suggesting that posttranscriptional mechanisms complement the transcriptional response in the regulation of gene expression by checkpoint signaling pathways in Saccharomyces cerevisiae [4].

Biological context of PAN2

  • Among these ORFs, two of them (YGL100w and YGL094c) are now known genes which encode well-characterized proteins (Seh1p, a nuclear pore protein, and Pan2p, a component of Pab1p-stimulated poly(A) ribonuclease, respectively) [5].

Other interactions of PAN2

  • In addition, we demonstrate that a deletion of PAN2, PAN3, or both resulted in similar increases in mRNA poly(A) tail lengths in vivo [6].
  • The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity [7].


  1. Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors. Grigull, J., Mnaimneh, S., Pootoolal, J., Robinson, M.D., Hughes, T.R. Mol. Cell. Biol. (2004) [Pubmed]
  2. The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Tucker, M., Valencia-Sanchez, M.A., Staples, R.R., Chen, J., Denis, C.L., Parker, R. Cell (2001) [Pubmed]
  3. Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal. Viswanathan, P., Ohn, T., Chiang, Y.C., Chen, J., Denis, C.L. J. Biol. Chem. (2004) [Pubmed]
  4. Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks. Hammet, A., Pike, B.L., Heierhorst, J. J. Biol. Chem. (2002) [Pubmed]
  5. Disruption and phenotypic analysis of six open reading frames from the left arm of Saccharomyces cerevisiae chromosome VII. Lillo, J.A., Andaluz, E., Cotano, C., Basco, R., Cueva, R., Correa, J., Larriba, G. Yeast (2000) [Pubmed]
  6. PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae. Brown, C.E., Tarun, S.Z., Boeck, R., Sachs, A.B. Mol. Cell. Biol. (1996) [Pubmed]
  7. The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity. Boeck, R., Tarun, S., Rieger, M., Deardorff, J.A., Müller-Auer, S., Sachs, A.B. J. Biol. Chem. (1996) [Pubmed]
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