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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HBS1  -  ribosome dissociation factor GTPase HBS1

Saccharomyces cerevisiae S288c

Synonyms: Elongation factor 1 alpha-like protein, YKR084C, YKR404
 
 
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High impact information on HBS1

  • Thus, Hbs1p and Dom34p may function together to help directly or indirectly facilitate the expression either of specific mRNAs or under certain cellular conditions [1].
  • The complete sequence of an 18,002 bp segment of Saccharomyces cerevisiae chromosome XI contains the HBS1, MRP-L20 and PRP16 genes, and six new open reading frames [2].
  • Dom34p and Hbs1p are similar to the translation termination factors eRF1 and eRF3 (refs 3, 4), indicating that these proteins might function in recognizing the stalled ribosome and triggering endonucleolytic cleavage [3].

References

  1. Novel G-protein complex whose requirement is linked to the translational status of the cell. Carr-Schmid, A., Pfund, C., Craig, E.A., Kinzy, T.G. Mol. Cell. Biol. (2002) [Pubmed]
  2. The complete sequence of an 18,002 bp segment of Saccharomyces cerevisiae chromosome XI contains the HBS1, MRP-L20 and PRP16 genes, and six new open reading frames. García-Cantalejo, J., Baladrón, V., Esteban, P.F., Santos, M.A., Bou, G., Remacha, M.A., Revuelta, J.L., Ballesta, J.P., Jiménez, A., del Rey, F. Yeast (1994) [Pubmed]
  3. Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation. Doma, M.K., Parker, R. Nature (2006) [Pubmed]
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