The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HBS1L  -  HBS1-like translational GTPase

Homo sapiens

Synonyms: DKFZp434g247, EF-1a, ERFS, HBS1, HBS1-like protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on HBS1L

  • Two genes, cMYB and HBS1L, demonstrated simultaneous transcriptional down-regulation in individuals with elevated HbF levels [1].
  • Transfection of K562 cells encoding human cDNA of cMYB and HBS1L genes showed that, although overexpression of ectopic cMYB inhibited gamma-globin gene expression, overexpression of HBS1L had no effect [1].
  • In contrast, mapping and analysis of c-myb neighboring genes (HBS1 and FLJ20069) showed that the expression of these genes did not correlate well with the presence of proviral insertions [2].
  • The phenotypic characterization of HBS1 demonstrated absence of hippurate hydrolysis, indole production, alpha-galactosidase, alpha- and beta-glucosidase activities in accordance with the B. aalborgi type strain [3].
  • Rapid identification of B. aalborgi isolate HBS1 was performed directly from faeces and rectal biopsies and subsequently from pure cultures by a genetic method based on 16S DNA restriction fragment length polymorphism (RFLP)-polymerase chain reaction (PCR) [3].

Biological context of HBS1L

  • Northern adapted QPM genotypes may have the potential to increase their lysine content even further, either by an increase in specific high-lysine-containing nonzein proteins, such as the synthesis of factor EF-1a, or by a further reduction in the 19 and 22 kDa alpha-zein in the endosperm or both [4].

Anatomical context of HBS1L

  • In the wheat system, however, both EF-1b and EF-1b' had the EF-Ts-like activity to stimulate EF-1a-dependent binding of aminoacyl-tRNA to ribosomes [5].

Analytical, diagnostic and therapeutic context of HBS1L

  • The new HBS1 isolate was only propagated in TSB broth and at electron microscopy it showed 4 endoflagella inserted at each tapered end [3].


  1. cMYB is involved in the regulation of fetal hemoglobin production in adults. Jiang, J., Best, S., Menzel, S., Silver, N., Lai, M.I., Surdulescu, G.L., Spector, T.D., Thein, S.L. Blood (2006) [Pubmed]
  2. Long-range effects of retroviral insertion on c-myb: overexpression may be obscured by silencing during tumor growth in vitro. Hanlon, L., Barr, N.I., Blyth, K., Stewart, M., Haviernik, P., Wolff, L., Weston, K., Cameron, E.R., Neil, J.C. J. Virol. (2003) [Pubmed]
  3. Rapid detection and identification of Brachyspira aalborgi from rectal biopsies and faeces of a patient. Calderaro, A., Villanacci, V., Conter, M., Ragni, P., Piccolo, G., Zuelli, C., Bommezzadri, S., Guégan, R., Zambelli, C., Perandin, F., Arcangeletti, M.C., Medici, M.C., Manca, N., Dettori, G., Chezzi, C. Res. Microbiol. (2003) [Pubmed]
  4. Assessment of the protein quality of 15 new northern adapted cultivars of quality protein maize using amino acid analysis. Zarkadas, C.G., Hamilton, R.I., Yu, Z.R., Choi, V.K., Khanizadeh, S., Rose, N.G., Pattison, P.L. J. Agric. Food Chem. (2000) [Pubmed]
  5. Occurrence of four subunits in high molecular weight forms of polypeptide chain elongation factor 1 from wheat embryo. Ejiri, S., Ebata, N., Kawamura, R., Katsumata, T. J. Biochem. (1983) [Pubmed]
WikiGenes - Universities