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Gene Review

DOM34  -  ribosome dissociation factor DOM34

Saccharomyces cerevisiae S288c

Synonyms: N2016, Protein DOM34, YNL001W
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High impact information on DOM34

  • Thus, Hbs1p and Dom34p may function together to help directly or indirectly facilitate the expression either of specific mRNAs or under certain cellular conditions [1].
  • Analysis of dom34 strains shows that progression through the G1 phase of the cell cycle is delayed, mutant cells enter meiosis aberrantly, and their ability to form pseudohyphae is significantly diminisehd [2].
  • Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes [2].
  • TOM34 codes for a putative RNA binding protein, and DOM34 defines a hypothetical polypeptide of 35 kDa, with no significant homology to known proteins [3].
  • ORF N2016 is immediately adjacent to the centromere, suggesting that it corresponds to the SPO1 gene, which is very tightly linked to the centromere at the left arm side of chromosome XIV (Mortimer et al., 1989) [4].

Biological context of DOM34


Physical interactions of DOM34

  • The comparison of eRF1 and Dom34 domains proposed to interact directly with eRF3 and Hbs1, respectively, highlights striking structural similarities with eRF1 motifs identified to be crucial for the binding to eRF3 [6].


  1. Novel G-protein complex whose requirement is linked to the translational status of the cell. Carr-Schmid, A., Pfund, C., Craig, E.A., Kinzy, T.G. Mol. Cell. Biol. (2002) [Pubmed]
  2. Yeast dom34 mutants are defective in multiple developmental pathways and exhibit decreased levels of polyribosomes. Davis, L., Engebrecht, J. Genetics (1998) [Pubmed]
  3. Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae. Lalo, D., Stettler, S., Mariotte, S., Gendreau, E., Thuriaux, P. Yeast (1994) [Pubmed]
  4. Nucleotide sequence analysis of an 8887 bp region of the left arm of yeast chromosome XIV, encompassing the centromere sequence. Verhasselt, P., Aert, R., Voet, M., Volckaert, G. Yeast (1994) [Pubmed]
  5. Two yeast chromosomes are related by a fossil duplication of their centromeric regions. Lalo, D., Stettler, S., Mariotte, S., Slonimski, P.P., Thuriaux, P. C. R. Acad. Sci. III, Sci. Vie (1993) [Pubmed]
  6. Structure of yeast Dom34: a protein related to translation termination factor Erf1 and involved in No-Go decay. Graille, M., Chaillet, M., van Tilbeurgh, H. J. Biol. Chem. (2008) [Pubmed]
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