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Gene Review

IZH2  -  Izh2p

Saccharomyces cerevisiae S288c

Synonyms: ADIPOR-like receptor IZH2, PHO36, Phosphate metabolism protein 36, UND327, YOL002C
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High impact information on IZH2

  • PHO36 functions upstream of RAS2 in the osmotin-induced apoptotic pathway [1].
  • We show here that the protein encoded by ORE20/PHO36 (YOL002c), a seven transmembrane domain receptor-like polypeptide that regulates lipid and phosphate metabolism, is an osmotin binding plasma membrane protein that is required for full sensitivity to osmotin [1].


  1. Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor. Narasimhan, M.L., Coca, M.A., Jin, J., Yamauchi, T., Ito, Y., Kadowaki, T., Kim, K.K., Pardo, J.M., Damsz, B., Hasegawa, P.M., Yun, D.J., Bressan, R.A. Mol. Cell (2005) [Pubmed]
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