Disease relevance of Adipor1

• Adiponectin replacement in OB mice inhibited the development of severe myocarditis by augmenting myocyte adiponectin receptor 1 reactivity [1].

High impact information on Adipor1

• Adiponectin receptor mRNA levels and adiponectin-stimulated phosphorylation of AMPK in skeletal muscle and liver were similar among MKR, wild-type, and ob/ob mice [2].
• Regulation of adiponectin receptor gene expression in diabetic mice [3].
• The reactivity of adiponectin receptor 1 in myocytes from OB mice on day 4 and day 8 after viral inoculation was significantly decreased compared with that in myocytes from WT mice; the OB mice also had elevated cardiac weights and severe inflammatory myocardial damage [1].

Biological context of Adipor1

• Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice [4].

Physical interactions of Adipor1

• Exogenously administered adiponectin may inhibit the progression of viral myocarditis through binding to the adiponectin receptor 1 in leptin-deficient conditions [1].

Analytical, diagnostic and therapeutic context of Adipor1

• Furthermore, RT-PCR revealed the expression of the adiponectin receptor AdipoR1 mRNA in mouse islets, however, with no difference in the degree of expression level between the two feeding groups [5].
• To clarify the regulation of adiponectin receptor gene expression in diabetic states, we examined mRNA levels of AdipoR1 in the muscles of diabetic animals by Northern blotting [3].

References