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Gene Review

ADIPOR1  -  adiponectin receptor 1

Homo sapiens

Synonyms: ACDCR1, Adiponectin receptor protein 1, CGI-45, CGI45, PAQR1, ...
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Disease relevance of ADIPOR1


Psychiatry related information on ADIPOR1

  • Methods: Using reverse transcription-polymerase chain reaction, we measured ADIPOR1 and ADIPOR2 mRNA levels in the lymphocytes of 59 obese patients, of whom 39 had normal glucose tolerance, 8 had impaired glucose tolerance or impaired fasting glucose, and 12 had type 2 diabetes, and of 21 women with restrictive anorexia nervosa [5].
  • A revised questionnaire (PAQ-R) was examined in the present study to determine the generalizability of psychometric properties when used with chronic pain patients [6].

High impact information on ADIPOR1


Biological context of ADIPOR1


Anatomical context of ADIPOR1


Associations of ADIPOR1 with chemical compounds


Physical interactions of ADIPOR1


Other interactions of ADIPOR1


Analytical, diagnostic and therapeutic context of ADIPOR1


  1. Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines. Chen, J., Tan, B., Karteris, E., Zervou, S., Digby, J., Hillhouse, E.W., Vatish, M., Randeva, H.S. Diabetologia (2006) [Pubmed]
  2. Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas. Rossi, G.P., Sticchi, D., Giuliani, L., Bernante, P., Zavattiero, S., Pessina, A.C., Nussdorfer, G.G. Int. J. Mol. Med. (2006) [Pubmed]
  3. Adipocytokine expression in placentas from pre-eclamptic and chronic hypertensive patients. Meller, M., Qiu, C., Kuske, B.T., Abetew, D.F., Muy-Rivera, M., Williams, M.A. Gynecol. Endocrinol. (2006) [Pubmed]
  4. Profiling adipocytokine secretion from creeping fat in Crohn's disease. Paul, G., Schäffler, A., Neumeier, M., Fürst, A., Bataillle, F., Buechler, C., Müller-Ladner, U., Schölmerich, J., Rogler, G., Herfarth, H. Inflamm. Bowel Dis. (2006) [Pubmed]
  5. Adiponectin receptors gene expression in lymphocytes of obese and anorexic patients. Alberti, L., Gilardini, L., Girola, A., Moro, M., Cavagnini, F., Invitti, C. Diabetes, obesity & metabolism (2007) [Pubmed]
  6. Psychometric properties of the Pain Attitudes Questionnaire (revised) in adult patients with chronic pain. Yong, H.H., Bell, R., Workman, B., Gibson, S.J. Pain (2003) [Pubmed]
  7. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Vaxillaire, M., Dechaume, A., Vasseur-Delannoy, V., Lahmidi, S., Vatin, V., Leprêtre, F., Boutin, P., Hercberg, S., Charpentier, G., Dina, C., Froguel, P. Diabetes (2006) [Pubmed]
  8. Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin. Katsiougiannis, S., Kapsogeorgou, E.K., Manoussakis, M.N., Skopouli, F.N. Arthritis Rheum. (2006) [Pubmed]
  9. Common Haplotypes at the Adiponectin Receptor 1 (ADIPOR1) Locus Are Associated With Increased Risk of Coronary Artery Disease in Type 2 Diabetes. Soccio, T., Zhang, Y.Y., Bacci, S., Mlynarski, W., Placha, G., Raggio, G., Di Paola, R., Marucci, A., Johnstone, M.T., Gervino, E.V., Abumrad, N.A., Klein, S., Trischitta, V., Doria, A. Diabetes (2006) [Pubmed]
  10. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Damcott, C.M., Ott, S.H., Pollin, T.I., Reinhart, L.J., Wang, J., O'connell, J.R., Mitchell, B.D., Shuldiner, A.R. Diabetes (2005) [Pubmed]
  11. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Stefan, N., Machicao, F., Staiger, H., Machann, J., Schick, F., Tschritter, O., Spieth, C., Weigert, C., Fritsche, A., Stumvoll, M., Häring, H.U. Diabetologia (2005) [Pubmed]
  12. Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome. Tan, B.K., Chen, J., Digby, J.E., Keay, S.D., Kennedy, C.R., Randeva, H.S. Diabetologia (2006) [Pubmed]
  13. Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study. Loos, R.J., Ruchat, S., Rankinen, T., Tremblay, A., P??russe, L., Bouchard, C. Am. J. Clin. Nutr. (2007) [Pubmed]
  14. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance. Wang, H., Zhang, H., Jia, Y., Zhang, Z., Craig, R., Wang, X., Elbein, S.C. Diabetes (2004) [Pubmed]
  15. Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. Tan, G.D., Debard, C., Funahashi, T., Humphreys, S.M., Matsuzawa, Y., Frayn, K.N., Karpe, F., Vidal, H. Diabetologia (2005) [Pubmed]
  16. Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients. Debard, C., Laville, M., Berbe, V., Loizon, E., Guillet, C., Morio-Liondore, B., Boirie, Y., Vidal, H. Diabetologia (2004) [Pubmed]
  17. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang, Y.T., Hu, T., Arterburn, M., Boyle, B., Bright, J.M., Emtage, P.C., Funk, W.D. J. Mol. Evol. (2005) [Pubmed]
  18. Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. Thomas, P., Pang, Y., Dong, J., Groenen, P., Kelder, J., de Vlieg, J., Zhu, Y., Tubbs, C. Endocrinology (2007) [Pubmed]
  19. The use of small interfering RNAs to inhibit adipocyte differentiation in human preadipocytes and fetal-femur-derived mesenchymal cells. Xu, Y., Mirmalek-Sani, S.H., Yang, X., Zhang, J., Oreffo, R.O. Exp. Cell Res. (2006) [Pubmed]
  20. Adiponectin Stimulates RANKL and Inhibits OPG Expression in Human Osteoblasts Through the MAPK Signaling Pathway. Luo, X.H., Guo, L.J., Xie, H., Yuan, L.Q., Wu, X.P., Zhou, H.D., Liao, E.Y. J. Bone Miner. Res. (2006) [Pubmed]
  21. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Siitonen, N., Pulkkinen, L., Mager, U., Lindström, J., Eriksson, J.G., Valle, T.T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Tuomilehto, J., Laakso, M., Uusitupa, M. Diabetologia (2006) [Pubmed]
  22. Changes in Placental Adipocytokine Gene Expression Associated with Gestational Diabetes MellitusA. Meller, M., Qiu, C., Vadachkoria, S., Abetew, D.F., Luthy, D.A., Williams, M.A. Physiological research / Academia Scientiarum Bohemoslovaca. (2006) [Pubmed]
  23. Identification of adiponectin and its receptors in human osteoblast-like cells and association of T45G polymorphism in exon 2 of adiponectin gene with lumbar spine bone mineral density in Korean women. Lee, W.Y., Rhee, E.J., Oh, K.W., Kim, S.Y., Jung, C.H., Yun, E.J., Baek, K.H., Kang, M.I., Kim, S.W. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
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