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Gene Review:

YRR1 - Yrr1p

Saccharomyces cerevisiae S288c

Synonyms: O3571, PDR2, Pleiotropic drug-resistance protein 2, YOR162C, Zinc finger transcription factor YRR1

Cui, Z. et al., Lucau-Danila, A. et al., Le Crom, S. et al., Zhang, X. et al.

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Disease relevance of YRR1

Disruption of the YRR1 gene leads to hypersensitivity to 4-NQO [1].

High impact information on YRR1

New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system [2].
Surprisingly, the absence of YRR1 releases the transcriptional activity of Yrm1, which then up-regulates 23 genes, 14 of which are also direct target genes of Yrr1 [3].
We have found that YRR1 expression is both controlled in a Pdr1p/Pdr3p-dependent manner and autoregulated [4].
Epistasis analysis demonstrated that 4-NQO resistances mediated by the YRR1 and YRR1-1 alleles require the presence of the SNQ2 gene that encodes a multidrug resistance ATP binding cassette superfamily protein responsible for 4-NQO export [1].
Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2 [1].

Biological context of YRR1

The wild-type YRR1 gene encodes a protein that contains a Zn(II)2Cys6-type zinc-finger motif [1].

Regulatory relationships of YRR1

Chromatin immunoprecipitation experiments confirmed that Yrm1 binds to the promoters of the up-regulated genes only in yeast strains from which YRR1 has been deleted [3].

References

Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Cui, Z., Shiraki, T., Hirata, D., Miyakawa, T. Mol. Microbiol. (1998) [Pubmed]
New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Le Crom, S., Devaux, F., Marc, P., Zhang, X., Moye-Rowley, W.S., Jacq, C. Mol. Cell. Biol. (2002) [Pubmed]
Competitive promoter occupancy by two yeast paralogous transcription factors controlling the multidrug resistance phenomenon. Lucau-Danila, A., Delaveau, T., Lelandais, G., Devaux, F., Jacq, C. J. Biol. Chem. (2003) [Pubmed]
Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae. Zhang, X., Cui, Z., Miyakawa, T., Moye-Rowley, W.S. J. Biol. Chem. (2001) [Pubmed]

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