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Gene Review

YRR1  -  Yrr1p

Saccharomyces cerevisiae S288c

Synonyms: O3571, PDR2, Pleiotropic drug-resistance protein 2, YOR162C, Zinc finger transcription factor YRR1
 
 
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Disease relevance of YRR1

 

High impact information on YRR1

  • New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system [2].
  • Surprisingly, the absence of YRR1 releases the transcriptional activity of Yrm1, which then up-regulates 23 genes, 14 of which are also direct target genes of Yrr1 [3].
  • We have found that YRR1 expression is both controlled in a Pdr1p/Pdr3p-dependent manner and autoregulated [4].
  • Epistasis analysis demonstrated that 4-NQO resistances mediated by the YRR1 and YRR1-1 alleles require the presence of the SNQ2 gene that encodes a multidrug resistance ATP binding cassette superfamily protein responsible for 4-NQO export [1].
  • Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2 [1].
 

Biological context of YRR1

  • The wild-type YRR1 gene encodes a protein that contains a Zn(II)2Cys6-type zinc-finger motif [1].
 

Regulatory relationships of YRR1

References

 
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