The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

YRR1  -  Yrr1p

Saccharomyces cerevisiae S288c

Synonyms: O3571, PDR2, Pleiotropic drug-resistance protein 2, YOR162C, Zinc finger transcription factor YRR1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of YRR1


High impact information on YRR1

  • New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system [2].
  • Surprisingly, the absence of YRR1 releases the transcriptional activity of Yrm1, which then up-regulates 23 genes, 14 of which are also direct target genes of Yrr1 [3].
  • We have found that YRR1 expression is both controlled in a Pdr1p/Pdr3p-dependent manner and autoregulated [4].
  • Epistasis analysis demonstrated that 4-NQO resistances mediated by the YRR1 and YRR1-1 alleles require the presence of the SNQ2 gene that encodes a multidrug resistance ATP binding cassette superfamily protein responsible for 4-NQO export [1].
  • Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2 [1].

Biological context of YRR1

  • The wild-type YRR1 gene encodes a protein that contains a Zn(II)2Cys6-type zinc-finger motif [1].

Regulatory relationships of YRR1


WikiGenes - Universities