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Gene Review:

MSB1 - Msb1p

Saccharomyces cerevisiae S288c

Synonyms: Morphogenesis-related protein MSB1, Multicopy suppressor of bud emergence 1, YOR188W

Bender, A. et al., Leitner, D. et al., Bender, A. et al.

Leitner, Wahl, Labudde, Krause, Diehl, Schmieder, Pires, Fossi, Wiedemann, Leidert, Oschkinat,

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High impact information on MSB1

This gene, named MSB1, maps between ADE9 and HIS3 on the right arm of chromosome XV [1].
Starting with a strain deleted for the chromosomal copy of MSB1 but containing MSB1 on a high-copy-number plasmid, mutants were identified in which MSB1 had become essential for viability [2].
The C-terminal PB1 domain of yeast cell division cycle 24 (CDC24p), a guanine-nucleotide exchange factor involved in cell polarity establishment, is known to interact with the PB1 domain occurring in bud emergence MSB1 interacting 1 (BEM1p) during the regulation of the yeast budding process via its OPR/PC/AID (OPCA) motif [3].

References

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1. Bender, A., Pringle, J.R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae. Bender, A., Pringle, J.R. Mol. Cell. Biol. (1991) [Pubmed]
The solution structure of an N-terminally truncated version of the yeast CDC24p PB1 domain shows a different beta-sheet topology. Leitner, D., Wahl, M., Labudde, D., Krause, G., Diehl, A., Schmieder, P., Pires, J.R., Fossi, M., Wiedemann, U., Leidert, M., Oschkinat, H. FEBS Lett. (2005) [Pubmed]

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