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Gene Review

MSB1  -  Msb1p

Saccharomyces cerevisiae S288c

Synonyms: Morphogenesis-related protein MSB1, Multicopy suppressor of bud emergence 1, YOR188W
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High impact information on MSB1

  • This gene, named MSB1, maps between ADE9 and HIS3 on the right arm of chromosome XV [1].
  • Starting with a strain deleted for the chromosomal copy of MSB1 but containing MSB1 on a high-copy-number plasmid, mutants were identified in which MSB1 had become essential for viability [2].
  • The C-terminal PB1 domain of yeast cell division cycle 24 (CDC24p), a guanine-nucleotide exchange factor involved in cell polarity establishment, is known to interact with the PB1 domain occurring in bud emergence MSB1 interacting 1 (BEM1p) during the regulation of the yeast budding process via its OPR/PC/AID (OPCA) motif [3].


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