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Gene Review:

ZCRB1 - zinc finger CCHC-type and RNA binding motif 1

Homo sapiens

Synonyms: MADP-1, MADP1, RBM36, SNRNP31, U11/U12 small nuclear ribonucleoprotein 31 kDa protein, ...

Wang, H. et al., Shibata-Sekiya, K.

Wang, Gao, Li, Wang, Hori, Sato,

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High impact information on ZCRB1

While isolating morphine-dependence-related genes with differential display, we cloned a novel human gene, zinc finger CCHC-type and RNA-binding motif 1 (ZCRB1, alias MADP-1) encoding a nuclear protein (217 residues) [1].
Transfection assay showed that ZCRB1 is located in the nucleoplasm, but outside the nucleolus [1].
The ZCRB1 gene consists of eight exons and seven introns [1].
ZCRB1 is characterized by an RNA-binding motif and a CCHC zinc finger motif [1].
ZCRB1 gene expression was stimulated by morphine, inhibited by 30-36 degrees C, and up-regulated by 39 degrees C incubation in SH-SY5Y neural cells [1].

Other interactions of ZCRB1

The dependences on ATP concentration of the extent of the fluorescence enhancement and the dissociation of actomyosin could be explained by assuming that these changes are associated with the formation of MADPP on one of the two heads of myosin [2].

References

Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Wang, H., Gao, M.X., Li, L., Wang, B., Hori, N., Sato, K. Genomics (2007) [Pubmed]
Reaction intermediates of myosin ATPase from scallop adductor muscles: nonidentical two-headed structure of striated adductor muscle myosin. Shibata-Sekiya, K. J. Biochem. (1982) [Pubmed]

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