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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

ZINC     zinc

Synonyms: Rheinzink, zincide, Merrillite, zincum, Jasad, ...
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Disease relevance of zinc


High impact information on zinc

  • Here we have generated a series of artificial Zn(2+) binding sites in a domain situated around the external ends of TMs 7 and 8 by taking advantage of the well-defined structural constraints for binding of the zinc(II) ion [3].
  • Results show that zinc exists in a metabolically labile islet compartment(s) as well as in secretory granules; and extra-granular zinc, although not directly associated with insulin storage, may act as a reservoir for granular zinc and may regulate insulin synthesis, storage, and secretion in ways as yet unknown [4].
  • A novel fluorescent chemosensor (L) demonstrates a remarkable selectivity and sensitivity for zinc(II) ion as evidenced from the solution characterisations and in vitro experiments using Hela cell lines [5].
  • Solvation structure of the zinc(II) ion in N,N-dimethylpropionamide (DMPA) was studied by Raman spectroscopy at varying temperature and by quantum mechanical calculations [6].
  • Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion [7].

Biological context of zinc


Gene context of zinc


Analytical, diagnostic and therapeutic context of zinc


  1. Dependence of hydrolysis of beta-lactams with a zinc(II)-beta-lactamase produced from Serratia marcescens (IMP-1) on pH and concentration of zinc(II) ion: dissociation of Zn(II) from IMP-1 in acidic medium. Goto, M., Yasuzawa, H., Higashi, T., Yamaguchi, Y., Kawanami, A., Mifune, S., Mori, H., Nakayama, H., Harada, K., Arakawa, Y. Biol. Pharm. Bull. (2003) [Pubmed]
  2. Effect of micronutrient supplementation on the growth of preschool children in China. Yang, Y.X., Han, J.H., Shao, X.P., He, M., Bian, L.H., Wang, Z., Wang, G.D., Men, J.H. Biomed. Environ. Sci. (2002) [Pubmed]
  3. Structural probing of a microdomain in the dopamine transporter by engineering of artificial Zn2+ binding sites. Norregaard, L., Visiers, I., Loland, C.J., Ballesteros, J., Weinstein, H., Gether, U. Biochemistry (2000) [Pubmed]
  4. 65Zinc and endogenous zinc content and distribution in islets in relationship to insulin content. Figlewicz, D.P., Forhan, S.E., Hodgson, A.T., Grodsky, G.M. Endocrinology (1984) [Pubmed]
  5. Novel zinc fluorescent probe bearing dansyl and aminoquinoline groups. Jiang, P., Chen, L., Lin, J., Liu, Q., Ding, J., Gao, X., Guo, Z. Chem. Commun. (Camb.) (2002) [Pubmed]
  6. Conformation of solvent N,N-dimethylpropionamide in the coordination sphere of the zinc(II) ion studied by Raman spectroscopy and DFT calculations. Umebayashi, Y., Mroz, B., Asada, M., Fujii, K., Matsumoto, K., Mune, Y., Probst, M., Ishiguro, S. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2005) [Pubmed]
  7. Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion. Kim, J.S., Yun, C.H. Toxicol. Lett. (2005) [Pubmed]
  8. Chemistry of zinc(II) fluorophore sensors. Kimura, E., Aoki, S. Biometals (2001) [Pubmed]
  9. Improved determination of bovine glutaminyl cyclase activity using precolumn derivatization and reversed-phase high-performance liquid chromatography with ultraviolet detection. Chikuma, T., Taguchi, K., Yamaguchi, M., Hojo, H., Kato, T. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
  10. Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Maines, M.D. Biochim. Biophys. Acta (1981) [Pubmed]
  11. Metal ion coordination of macromolecular bioligands: formation of zinc(II) complex of hyaluronic acid. Burger, K., Illés, J., Gyurcsik, B., Gazdag, M., Forrai, E., Dékány, I., Mihályfi, K. Carbohydr. Res. (2001) [Pubmed]
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