Disease relevance of zinc

• Dependence of hydrolysis of beta-lactams with a zinc(II)-beta-lactamase produced from Serratia marcescens (IMP-1) on pH and concentration of zinc(II) ion: dissociation of Zn(II) from IMP-1 in acidic medium [1].
• CONCLUSION: Zinc and Zinc + Calcium supplementation can improve the height gain, and vitamin A can improve weight gain in growth retarded preschool children, but do not affect the maturity of bone [2].

High impact information on zinc

• Here we have generated a series of artificial Zn(2+) binding sites in a domain situated around the external ends of TMs 7 and 8 by taking advantage of the well-defined structural constraints for binding of the zinc(II) ion [3].
• Results show that zinc exists in a metabolically labile islet compartment(s) as well as in secretory granules; and extra-granular zinc, although not directly associated with insulin storage, may act as a reservoir for granular zinc and may regulate insulin synthesis, storage, and secretion in ways as yet unknown [4].
• A novel fluorescent chemosensor (L) demonstrates a remarkable selectivity and sensitivity for zinc(II) ion as evidenced from the solution characterisations and in vitro experiments using Hela cell lines [5].
• Solvation structure of the zinc(II) ion in N,N-dimethylpropionamide (DMPA) was studied by Raman spectroscopy at varying temperature and by quantum mechanical calculations [6].
• Inhibition of human cytochrome P450 3A4 activity by zinc(II) ion [7].

Biological context of zinc

• The biological role of the zinc(II) ion has been recognized in DNA and RNA synthesis, apoptosis, gene expression, or protein structure and function [8].

Gene context of zinc

• Glutaminyl cyclase activity was strongly inhibited by zinc(II) ion and 1,10-phenanthroline [9].
• Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat [10].

Analytical, diagnostic and therapeutic context of zinc

• Conformation of solvent N,N-dimethylpropionamide in the coordination sphere of the zinc(II) ion studied by Raman spectroscopy and DFT calculations [6].
• The coordination of zinc(II) ion to hyaluronate (Hya), a natural copolymer, in aqueous solution at pH 6 was investigated by potentiometric and circular dichroism (CD) spectroscopic methods, and by monitoring the changes in macroscopic properties by high-precision measurements [11].

References