The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ISU2  -  putative iron-binding protein ISU2

Saccharomyces cerevisiae S288c

Synonyms: Iron sulfur cluster assembly protein 2, mitochondrial, Iron sulfur cluster scaffold protein 2, NUA2, YOR226C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ISU2


High impact information on ISU2

  • The mitochondrial proteins Isu1p and Isu2p play an essential role in the maturation of cellular iron-sulfur (Fe/S) proteins in eukaryotes [2].
  • Isu1, Isu2, and Nfu1 are located in the mitochondrial matrix [3].
  • The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins [4].
  • As with other yeast genes implicated in Fe/S protein assembly, deletion of either ISU1 or ISU2 results in increased accumulation of iron within the mitochondria, loss of activity of the [4Fe-4S] aconitase enzyme, and suppression of oxidative damage in cells lacking cytosolic copper/zinc superoxide dismutase [1].

Physical interactions of ISU2

  • Consistent with this idea, these Isu1p mutants were capable of binding an Fe/S cluster in vivo but failed to restore the growth and Fe/S cluster assembly defects of a Isu1p/Isu2p-deficient yeast strain [5].

Other interactions of ISU2


  1. Saccharomyces cerevisiae ISU1 and ISU2: members of a well-conserved gene family for iron-sulfur cluster assembly. Garland, S.A., Hoff, K., Vickery, L.E., Culotta, V.C. J. Mol. Biol. (1999) [Pubmed]
  2. Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. Mühlenhoff, U., Gerber, J., Richhardt, N., Lill, R. EMBO J. (2003) [Pubmed]
  3. Evidence for a conserved system for iron metabolism in the mitochondria of Saccharomyces cerevisiae. Schilke, B., Voisine, C., Beinert, H., Craig, E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. Gerber, J., Neumann, K., Prohl, C., Mühlenhoff, U., Lill, R. Mol. Cell. Biol. (2004) [Pubmed]
  5. The Hsp70 chaperone Ssq1p is dispensable for iron-sulfur cluster formation on the scaffold protein Isu1p. Dutkiewicz, R., Marszalek, J., Schilke, B., Craig, E.A., Lill, R., Mühlenhoff, U. J. Biol. Chem. (2006) [Pubmed]
WikiGenes - Universities