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Gene Review

ISCU  -  iron-sulfur cluster assembly enzyme

Homo sapiens

Synonyms: 2310020H20Rik, HML, ISU2, Iron-sulfur cluster assembly enzyme ISCU, mitochondrial, IscU, ...
 
 
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Disease relevance of ISCU

  • Conceptual translation of the hnifU cDNA yielded a protein product bearing 77% and 70% amino acid identity to NifU-like hypothetical proteins from Haemophilus influenzae and Saccharomyces cerevisiae, respectively, and 40-44% identity to the N-terminal regions of NifU proteins from several diazatrophs (i.e., nitrogen-fixing organisms) [1].
  • Our results demonstrated that against the human colon adenocarcinoma cell line GC3/c1, LY219703 is a more potent cytotoxic agent than N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea (Sulofenur; ISCU), whereas a subline selected for resistance to ISCU was cross-resistant to LY219703, suggesting a similar mechanism of action or resistance [2].
 

High impact information on ISCU

 

Biological context of ISCU

  • Suppression of human ISCU by RNAi not only inactivated mitochondrial and cytosolic aconitases in a compartment-specific manner but also inappropriately activated the iron regulatory proteins and disrupted intracellular iron homeostasis [4].
 

Associations of ISCU with chemical compounds

  • Thus, the cytosolic form of ISCS is a functional cysteine desulfurase that can collaborate with cytosolic ISCU to promote de novo iron-sulfur cluster formation [3].

References

 
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