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Gene Review:

ABP140 - Abp140p

Saccharomyces cerevisiae S288c

Synonyms: Actin-binding protein of 140 kDa, TRM140, YOR239W, YOR240W, tRNA methyltransferase of 140 kDa, ...

Asakura, T. et al., Yang, H.C. et al., Farabaugh, P.J. et al.

Farabaugh, Kramer, Vallabhaneni, Raman,

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High impact information on ABP140

Time-lapse imaging of Abp140p-GFP revealed an apparent increase in the length of bud-associated actin cables [1].
Analysis of movement of Abp140p-GFP fiduciary marks on bud-associated cables and fluorescence loss in photobleaching experiments revealed that this apparent elongation occurs by assembly of new material at the end of the cable within the bud and movement of the opposite end of the cable toward the tip of the mother cell distal to the bud [1].
However, elimination of ABP140 by gene disruption did not show a deleterious effect on cell growth or affect the organization of F-actin [2].
A search with the partial amino acid sequences of ABP140 against the Saccharomyces Genome Database revealed that the open reading frame of the ABP140 gene (ABP140) corresponded to YOR239W fused with YOR240W by the +1 translational frame shift [2].
We find that frameshifting has persisted in two structural genes in budding yeasts, ABP140 and EST3 for about 150 million years [3].

Co-localisations of ABP140

Indirect immunofluorescence study demonstrated that ABP140 was colocalized with both cortical actin patches and cytoplasmic actin cables in intact cells [2].

References

Actin cable dynamics in budding yeast. Yang, H.C., Pon, L.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae. Asakura, T., Sasaki, T., Nagano, F., Satoh, A., Obaishi, H., Nishioka, H., Imamura, H., Hotta, K., Tanaka, K., Nakanishi, H., Takai, Y. Oncogene (1998) [Pubmed]
Evolution of +1 Programmed Frameshifting Signals and Frameshift-Regulating tRNAs in the Order Saccharomycetales. Farabaugh, P.J., Kramer, E., Vallabhaneni, H., Raman, A. J. Mol. Evol. (2006) [Pubmed]

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