The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DGA1  -  diacylglycerol O-acyltransferase

Saccharomyces cerevisiae S288c

Synonyms: Acyl-CoA:monoacylglycerol acyltransferase, DGAT, Diacylglycerol O-acyltransferase 1, MGAT, YOR245C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on DGA1

  • Using a dga1lro1are1are2 quadruple mutant transformed with plasmids bearing inducible DGA1, LRO1, or ARE2 we demonstrate that TAG synthesis contributes more efficiently to lipid particle proliferation than synthesis of STE [1].
  • In vitro microsomal assays verified that DGA1 and ARE2 mediate acyl-CoA:diacylglycerol acyltransferase reactions [2].
  • The DGA1 gene determines a second triglyceride synthetic pathway in yeast [2].
  • In a dga1 deletion strain, the DAGAT activity in lipid particles is dramatically reduced, whereas the activity in microsomes is affected only to a minor extent [3].
  • With the exception of Dga1p, whose activity is partially localized to lipid particles, TAG and STE forming enzymes are restricted to the endoplasmic reticulum [4].

Biological context of DGA1


Other interactions of DGA1

  • The contribution of two lipid particle-associated proteins (namely Tgl1p and Dga1p) to this process is described [6].


  1. A yeast strain lacking lipid particles bears a defect in ergosterol formation. Sorger, D., Athenstaedt, K., Hrastnik, C., Daum, G. J. Biol. Chem. (2004) [Pubmed]
  2. The DGA1 gene determines a second triglyceride synthetic pathway in yeast. Oelkers, P., Cromley, D., Padamsee, M., Billheimer, J.T., Sturley, S.L. J. Biol. Chem. (2002) [Pubmed]
  3. Synthesis of triacylglycerols by the acyl-coenzyme A:diacyl-glycerol acyltransferase Dga1p in lipid particles of the yeast Saccharomyces cerevisiae. Sorger, D., Daum, G. J. Bacteriol. (2002) [Pubmed]
  4. Dynamics of neutral lipid storage and mobilization in yeast. Daum, G., Wagner, A., Czabany, T., Athenstaedt, K. Biochimie (2007) [Pubmed]
  5. Triacylglycerol biosynthesis in yeast. Sorger, D., Daum, G. Appl. Microbiol. Biotechnol. (2003) [Pubmed]
  6. Lipid dynamics in yeast under haem-induced unsaturated fatty acid and/or sterol depletion. Ferreira, T., Régnacq, M., Alimardani, P., Moreau-Vauzelle, C., Bergès, T. Biochem. J. (2004) [Pubmed]
WikiGenes - Universities