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Gene Review:

PDR10 - ATP-binding cassette multidrug transporter...

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent permease PDR10, YOR328W

Parle-McDermott, A.G. et al., Fay, J.C. et al., Wolfger, H. et al., Decottignies, A. et al.

Fay, Benavides,

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High impact information on PDR10

We have identified two new ABC transporter-encoding genes, PDR10 and PDR15, which were up-regulated by the PDR1-3 mutation [1].
Although noncoding and coding sequences show substantial variability in ratios of polymorphism to divergence, two of the loci, MLS1 and PDR10, show a higher rate of polymorphism at noncoding compared to synonymous sites [2].
In addition, in vitro band shift assays demonstrate that a GST-Pdr1 fusion protein can bind to the PDREs of PDR10 and PDR15 [3].
Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I [4].

Other interactions of PDR10

PDR10 encodes a protein highly similar to the pleiotropic drug resistance protein Pdr5p [4].

References

ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. Decottignies, A., Grant, A.M., Nichols, J.W., de Wet, H., McIntosh, D.B., Goffeau, A. J. Biol. Chem. (1998) [Pubmed]
Hypervariable noncoding sequences in Saccharomyces cerevisiae. Fay, J.C., Benavides, J.A. Genetics (2005) [Pubmed]
The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators. Wolfger, H., Mahé, Y., Parle-McDermott, A., Delahodde, A., Kuchler, K. FEBS Lett. (1997) [Pubmed]
Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I. Parle-McDermott, A.G., Hand, N.J., Goulding, S.E., Wolfe, K.H. Yeast (1996) [Pubmed]

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PDR4	Arabidopsis thaliana
KLLA0F21692g	Kluyveromyces lactis NRRL Y-1140
MGG_13624	Magnaporthe oryzae 70-15
NCU05591	Neurospora crassa OR74A
PDR5	Saccharomyces cerevisiae S288c
PDR15	Saccharomyces cerevisiae S288c
bfr1	Schizosaccharomyces pombe 972h-

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