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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PDR15  -  ATP-binding cassette multidrug transporter...

Saccharomyces cerevisiae S288c

Synonyms: ATP-dependent permease PDR15, D9509.24, YDR406W
 
 
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High impact information on PDR15

  • The Pdr15p ABC protein is the closest homologue of the multidrug efflux transporter Pdr5p, which mediates pleiotropic drug resistance to hundreds of unrelated compounds [1].
  • Interestingly, Pdr15p becomes most abundant when cells exit the exponential growth phase, whereas its closest homologue, Pdr5p, disappears after exponential growth [1].
  • Remarkably, however, Pdr15p induction bypasses upstream components of the high osmolarity glycerol (HOG) pathway including the Hog1p and Pbs2p kinases as well as the dedicated HOG cell surface sensors [1].
  • In this study, we show that the plasma membrane protein Pdr15p displays limited drug transport capacity, mediating chloramphenicol and detergent tolerance [1].
  • We have identified two new ABC transporter-encoding genes, PDR10 and PDR15, which were up-regulated by the PDR1-3 mutation [2].

References

  1. The yeast Pdr15p ATP-binding cassette (ABC) protein is a general stress response factor implicated in cellular detoxification. Wolfger, H., Mamnun, Y.M., Kuchler, K. J. Biol. Chem. (2004) [Pubmed]
  2. ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. Decottignies, A., Grant, A.M., Nichols, J.W., de Wet, H., McIntosh, D.B., Goffeau, A. J. Biol. Chem. (1998) [Pubmed]
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