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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SNX3  -  Snx3p

Saccharomyces cerevisiae S288c

Synonyms: GRD19, Golgi retention deficient protein 19, Sorting nexin-3, YOR357C
 
 
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High impact information on SNX3

  • Using an in vitro binding assay, Grd19p was found to interact physically with the cytosolic domain of DPAP A [1].
  • A grd19 null mutation causes rapid mislocalization of the late-Golgi membrane proteins A-ALP and Kex2p to the vacuole [1].
  • In a yeast mutant that accumulates an exaggerated form of the prevacuolar compartment (vps27), Grd19p was observed to localize to this compartment [1].
  • In contrast to previously identified genes involved in late-Golgi membrane protein localization, grd19 mutations cause only minor effects on vacuolar protein sorting [1].
  • Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate [2].
 

Other interactions of SNX3

  • In this study, we report the identification of a new gene, GRD19, involved in the localization of the model late-Golgi membrane protein A-ALP (consisting of the cytosolic domain of dipeptidyl aminopeptidase A [DPAP A] fused to the transmembrane and lumenal domains of the alkaline phosphatase [ALP]), which localizes to the yeast TGN [1].

References

  1. Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p. Voos, W., Stevens, T.H. J. Cell Biol. (1998) [Pubmed]
  2. Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate. Zhou, C.Z., de La Sierra-Gallay, I.L., Quevillon-Cheruel, S., Collinet, B., Minard, P., Blondeau, K., Henckes, G., Aufrère, R., Leulliot, N., Graille, M., Sorel, I., Savarin, P., de la Torre, F., Poupon, A., Janin, J., van Tilbeurgh, H. J. Biol. Chem. (2003) [Pubmed]
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