The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FKH1  -  Fkh1p

Saccharomyces cerevisiae S288c

Synonyms: Fork head protein homolog 1, YIL131C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on FKH1

  • The fkh1 fkh2 mutant also displays aberrant regulation of the 'SIC1' cluster, whose member genes are expressed in the M-G1 interval and are involved in mitotic exit [1].
  • Finally, the fkh1 fkh2 mutant displays a constitutive pseudohyphal morphology, indicating that Fkh1 and Fkh2 may help control the switch to this mode of growth [1].
  • Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer [2].
  • Regions A, D, and E each bind in vivo the transcription activator forkhead proteins Fkh1p and Fkh2p and their associated Ndd1p, although there are no adjacent open reading frames (ORFs) [2].
  • The roles of DNA and Mcm1p interactions in determining the overlapping and distinct functions of the yeast cell cycle regulatory transcription factors Fkh1p and Fkh2p were examined [3].

Biological context of FKH1


Physical interactions of FKH1

  • Here we show that Mcm1 binding is required for both the transcription of the noncoding RNAs and Fkh1 binding [7].

Other interactions of FKH1

  • Another closely related forkhead protein, Fkh1p, is also recruited to the CLB2 promoter in vivo [5].
  • FKH1 was isolated as a gene that, when expressed in multiple copies, could substitute for the function of SIR1 in silencing HMRa [4].
  • We conclude that the role of Mcm1 in RE is to open chromatin around the conserved domains and activate transcription; this facilitates Fkh1 binding and the level of this binding determines the level of donor preference [7].

Analytical, diagnostic and therapeutic context of FKH1

  • Furthermore, investigation of the relationship between Fkh2 and a related forkhead protein Fkh1 demonstrates that these proteins act in overlapping pathways to regulate cell morphology and cell separation [8].


  1. Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Zhu, G., Spellman, P.T., Volpe, T., Brown, P.O., Botstein, D., Davis, T.N., Futcher, B. Nature (2000) [Pubmed]
  2. Saccharomyces forkhead protein Fkh1 regulates donor preference during mating-type switching through the recombination enhancer. Sun, K., Coïc, E., Zhou, Z., Durrens, P., Haber, J.E. Genes Dev. (2002) [Pubmed]
  3. Mechanisms controlling differential promoter-occupancy by the yeast forkhead proteins Fkh1p and Fkh2p: implications for regulating the cell cycle and differentiation. Hollenhorst, P.C., Pietz, G., Fox, C.A. Genes Dev. (2001) [Pubmed]
  4. Forkhead genes in transcriptional silencing, cell morphology and the cell cycle. Overlapping and distinct functions for FKH1 and FKH2 in Saccharomyces cerevisiae. Hollenhorst, P.C., Bose, M.E., Mielke, M.R., Müller, U., Fox, C.A. Genetics (2000) [Pubmed]
  5. Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Kumar, R., Reynolds, D.M., Shevchenko, A., Shevchenko, A., Goldstone, S.D., Dalton, S. Curr. Biol. (2000) [Pubmed]
  6. A forkhead transcription factor is important for true hyphal as well as yeast morphogenesis in Candida albicans. Bensen, E.S., Filler, S.G., Berman, J. Eukaryotic Cell (2002) [Pubmed]
  7. Yeast recombination enhancer is stimulated by transcription activation. Ercan, S., Reese, J.C., Workman, J.L., Simpson, R.T. Mol. Cell. Biol. (2005) [Pubmed]
  8. The forkhead protein Fkh2 is a component of the yeast cell cycle transcription factor SFF. Pic, A., Lim, F.L., Ross, S.J., Veal, E.A., Johnson, A.L., Sultan, M.R., West, A.G., Johnston, L.H., Sharrocks, A.D., Morgan, B.A. EMBO J. (2000) [Pubmed]
WikiGenes - Universities