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Gene Review:

CST6 - Cst6p

Saccharomyces cerevisiae S288c

Synonyms: ACA2, ATF/CREB activator 2, Chromosome stability protein CST6, SHF1, YIL036W

Garcia-Gimeno, M.A. et al., Velmurugan, S. et al., Rep, M. et al.

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Disease relevance of CST6

The Shf1 protein expressed in Escherichia coli can bind with high specificity to the STB sequence in vitro [1].

High impact information on CST6

In addition, Acr1 does not affect a number of phenotypes that arise from loss of Aca2 [2].
Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress [2].
In a yeast strain deleted for the SHF1 locus, a 2 micrometer circle-derived plasmid shows relatively poor stability [1].
However, the two other yeast CRE-binding proteins, Aca1p and Aca2p, are not involved in regulation of the GRE2 promoter under osmotic stress [3].

References

The 2 micrometer plasmid stability system: analyses of the interactions among plasmid- and host-encoded components. Velmurugan, S., Ahn, Y.T., Yang, X.M., Wu, X.L., Jayaram, M. Mol. Cell. Biol. (1998) [Pubmed]
Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Garcia-Gimeno, M.A., Struhl, K. Mol. Cell. Biol. (2000) [Pubmed]
The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Rep, M., Proft, M., Remize, F., Tamás, M., Serrano, R., Thevelein, J.M., Hohmann, S. Mol. Microbiol. (2001) [Pubmed]

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