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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Twist1  -  twist family bHLH transcription factor 1

Rattus norvegicus

 
 
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High impact information on Twist1

  • Intravenous cotreatment with PBN and thalidomide (gavage) in rabbits restored normal patterns and localization of Twist, Fgf-8, and Fgf-10 expression [1].
  • Several factors such as Twist, Msx2, fibroblast growth factors (Fgfs), bone morphogenetic proteins (Bmps) and transforming growth factors-beta (Tgf-betas) regulate suture patency, likely by interacting with one another [2].
 

Other interactions of Twist1

  • NF-kappaB and regulatory genes that initiate and maintain limb outgrowth and development, such as Twist and Fgf-10, are selectively expressed in the PZ [1].

References

  1. Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. Hansen, J.M., Gong, S.G., Philbert, M., Harris, C. Dev. Dyn. (2002) [Pubmed]
  2. Transforming growth factor-beta3 (Tgf-beta3) down-regulates Tgf-beta3 receptor type I (Tbetar-I) during rescue of cranial sutures from osseous obliteration. Opperman, L.A., Galanis, V., Williams, A.R., Adab, K. Orthodontics & craniofacial research. (2002) [Pubmed]
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