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Gene Review:

Fgf8 - fibroblast growth factor 8

Rattus norvegicus

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High impact information on Fgf8

Both inhibition of FGF receptor activation and inhibition of Fgf8 function in vitro affect formation of the trochlear projection within explants in a manner consistent with a guidance function of Fgf8 during trochlear axon navigation [1].
Neutralization of endogenous TGF-beta, Shh, or FGF8 significantly reduced number of dopaminergic neurons [2].
In situ hybridization showed a preferential decrease in Twist, Fgf-8, and Fgf-10 expression after thalidomide treatment (400 mg/kg per day) in rabbit embryos [3].
We found that a combination of 50 ng/ml fibroblast growth factor 8, 10 ng/ml glial cell line-derived neurotrophic factor and 10 microM forskolin facilitated the differentiation of human fetal mesencephalic progenitor cells into dopaminergic neurons in vitro [4].
Rat Fgf8 and Fgf17 genes, consisting of five exons, were located within AC096326.7 and AC097410.12 genome sequences, respectively [5].

Biological context of Fgf8

CONCLUSIONS: The combined effects of increased cell death, decreased cell proliferation, reduction of Fgf8 expression, and intense reduction of Bmp4 expression in the anterior mesenchyme may play an important role in the development of tibial ray deficiency induced by busulfan [6].

Analytical, diagnostic and therapeutic context of Fgf8

RESULTS: In situ hybridization showed reductions in Fgf8 and Bmp4 expression [6].

References

Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8. Irving, C., Malhas, A., Guthrie, S., Mason, I. Development (2002) [Pubmed]
TGF-beta promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8. Roussa, E., Farkas, L.M., Krieglstein, K. Neurobiol. Dis. (2004) [Pubmed]
Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. Hansen, J.M., Gong, S.G., Philbert, M., Harris, C. Dev. Dyn. (2002) [Pubmed]
Distinct efficacy of pre-differentiated versus intact fetal mesencephalon-derived human neural progenitor cells in alleviating rat model of Parkinson's disease. Wang, X., Lu, Y., Zhang, H., Wang, K., He, Q., Wang, Y., Liu, X., Li, L., Wang, X. Int. J. Dev. Neurosci. (2004) [Pubmed]
Comparative genomics on FGF8, FGF17, and FGF18 orthologs. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
Developmental abnormalities in rat embryos leading to tibial ray deficiencies induced by busulfan. Otsuji, M., Takahara, M., Naruse, T., Guan, D., Harada, M., Zhe, P., Takagi, M., Ogino, T. Birth defects research. Part A, Clinical and molecular teratology. (2005) [Pubmed]

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FGF8	Bos taurus
fgf8a	Danio rerio
FGF8	Gallus gallus
FGF8	Homo sapiens
Fgf8	Mus musculus
fgf8	Xenopus (Silurana) tropicalis

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