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Gene Review

Fgf10  -  fibroblast growth factor 10

Rattus norvegicus

Synonyms: FGF-10, Fibroblast growth factor 10
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Disease relevance of Fgf10


High impact information on Fgf10

  • FGF10, which binds the same receptor as FGF7, did not support transdifferentiation when used in place of FGF7 [3].
  • Recombinant FGF10 protein specifically stimulated growth of Dunning epithelial and BPH1 prostatic epithelial cell lines, but had no effect on growth of Dunning stromal cells or primary SV mesenchyme [4].
  • During induction of the SV, FGF10 mRNA was present in mesenchyme surrounding the lower Wolffian ducts and, at later stages, FGF10 transcripts became restricted to mesenchymal cells subadjacent to the serosa [4].
  • While FGF10 transcript levels increased after treatment with testosterone in the SV (but not VP), these changes were not sensitive to anti-androgen treatment, and thus it is likely that FGF10 mRNA was not directly regulated by testosterone [4].
  • Furthermore, FGF10 protein stimulated the development of ventral prostate and seminal vesicle organ rudiments in serum-free organ culture [4].

Biological context of Fgf10


Anatomical context of Fgf10


Associations of Fgf10 with chemical compounds

  • Although expression of Fgf10, Nkx3.1, and Ptc was increased in both prostate lobes, other genes were regulated by testosterone in a lobe-specific manner [5].
  • FGF-10 requires 1.4 times higher NaCl for elution from immobilized heparin than does FGF-7 and binds to four times the number of sites on the pericellular matrix of epithelial cells [7].
  • Additionally, development induced by FGF10 was not inhibited by the addition of the anti-androgen Cyproterone Acetate demonstrating that the effects of FGF10 were not mediated by the androgen receptor [4].
  • Intravenous cotreatment with PBN and thalidomide (gavage) in rabbits restored normal patterns and localization of Twist, Fgf-8, and Fgf-10 expression [8].
  • Chlorate also inhibited migration of LgE toward beads soaked in FGF10 [9].

Regulatory relationships of Fgf10


Other interactions of Fgf10


Analytical, diagnostic and therapeutic context of Fgf10


  1. Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Ishiwata, T., Naito, Z., Lu, Y.P., Kawahara, K., Fujii, T., Kawamoto, Y., Teduka, K., Sugisaki, Y. Exp. Mol. Pathol. (2002) [Pubmed]
  2. Defective fibroblast growth factor signaling allows for nonbranching growth of the respiratory-derived fistula tract in esophageal atresia with tracheoesophageal fistula. Crisera, C.A., Maldonado, T.S., Longaker, M.T., Gittes, G.K. J. Pediatr. Surg. (2000) [Pubmed]
  3. Induction of alveolar type II cell differentiation in embryonic tracheal epithelium in mesenchyme-free culture. Shannon, J.M., Gebb, S.A., Nielsen, L.D. Development (1999) [Pubmed]
  4. Prostatic growth and development are regulated by FGF10. Thomson, A.A., Cunha, G.R. Development (1999) [Pubmed]
  5. Androgen regulation of prostate morphoregulatory gene expression: Fgf10-dependent and -independent pathways. Pu, Y., Huang, L., Birch, L., Prins, G.S. Endocrinology (2007) [Pubmed]
  6. Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching. Pu, Y., Huang, L., Prins, G.S. Dev. Biol. (2004) [Pubmed]
  7. Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate. Lu, W., Luo, Y., Kan, M., McKeehan, W.L. J. Biol. Chem. (1999) [Pubmed]
  8. Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide. Hansen, J.M., Gong, S.G., Philbert, M., Harris, C. Dev. Dyn. (2002) [Pubmed]
  9. Chondroitin sulfate proteoglycans are required for lung growth and morphogenesis in vitro. Shannon, J.M., McCormick-Shannon, K., Burhans, M.S., Shangguan, X., Srivastava, K., Hyatt, B.A. Am. J. Physiol. Lung Cell Mol. Physiol. (2003) [Pubmed]
  10. Fibroblast growth factor-10 prevents asbestos-induced alveolar epithelial cell apoptosis by a mitogen-activated protein kinase-dependent mechanism. Upadhyay, D., Panduri, V., Kamp, D.W. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
  11. Fibroblast growth factor receptors and their ligands in the adult rat kidney. Cancilla, B., Davies, A., Cauchi, J.A., Risbridger, G.P., Bertram, J.F. Kidney Int. (2001) [Pubmed]
  12. Spatially restricted expression of fibroblast growth factor-10 mRNA in the rat brain. Hattori, Y., Yamasaki, M., Konishi, M., Itoh, N. Brain Res. Mol. Brain Res. (1997) [Pubmed]
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