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Gene Review:

WAR1 - War1p

Saccharomyces cerevisiae S288c

Synonyms: Weak acid resistance protein 1, YML076C

Kren, A. et al., Schüller, C. et al., Hazelwood, L.A. et al.

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Disease relevance of WAR1

Sorbate hypersensitivity was detected in mutants of the shikimate biosynthesis pathway, strains lacking the PDR12 efflux pump or WAR1, a transcription factor mediating stress induction of PDR12 [1].

High impact information on WAR1

The appearance of phosphorylated War1p isoforms coincides with transcriptional activation of PDR12 [2].
Our results suggest that weak acid stress triggers phosphorylation and perhaps activation of War1p [2].
In turn, War1p activation is necessary for the induction of PDR12 through a novel signal transduction event that elicits weak organic acid stress adaptation [2].
Moreover, a novel War1p- and Msn2p/4p-independent regulon that includes HSP30 was identified [1].

Biological context of WAR1

The hypothesis that PDR12 is involved in export of natural products of amino acid catabolism was evaluated by analyzing the phenotype of null mutants in PDR12 or in WAR1, its positive transcriptional regulator [3].

References

Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Schüller, C., Mamnun, Y.M., Mollapour, M., Krapf, G., Schuster, M., Bauer, B.E., Piper, P.W., Kuchler, K. Mol. Biol. Cell (2004) [Pubmed]
War1p, a novel transcription factor controlling weak acid stress response in yeast. Kren, A., Mamnun, Y.M., Bauer, B.E., Schüller, C., Wolfger, H., Hatzixanthis, K., Mollapour, M., Gregori, C., Piper, P., Kuchler, K. Mol. Cell. Biol. (2003) [Pubmed]
A new physiological role for Pdr12p in Saccharomyces cerevisiae: export of aromatic and branched-chain organic acids produced in amino acid catabolism. Hazelwood, L.A., Tai, S.L., Boer, V.M., de Winde, J.H., Pronk, J.T., Daran, J.M. FEMS Yeast Res. (2006) [Pubmed]

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AGOS_AER153W	Ashbya gossypii ATCC 10895
KLLA0B04620g	Kluyveromyces lactis NRRL Y-1140

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