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Gene Review

HSP30  -  Hsp30p

Saccharomyces cerevisiae S288c

Synonyms: 30 kDa heat shock protein, YCR021C, YCR21C
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Disease relevance of HSP30


High impact information on HSP30


Biological context of HSP30

  • We showed that the HSP30 promoter can induce high gene expression during late stationary phase and remains active until the end of the wine fermentation process [7].
  • One ORF showed considerable homology (46%) to a hypothetical chromosome III gene; another, putatively very hydrophobic gene product, was 30% identical to the heat-shock protein HSP30 [8].
  • Mutation of the Thr-912 residue within the C-terminal domain of H+-ATPase, a potential site of phosphorylation by the Ca2+-calmodulin-dependent protein kinase, also abolishes any effect of Hsp30 [9].
  • Through in vivo pulse-labelling of plasma membrane proteins synthesised before and during heat shock, followed by subcellular fractionation, it was shown that hsp30 is the only protein induced by the yeast heat-shock response that substantially copurifies with plasma membranes [10].
  • Consistent with the role of Hsp30 being energy conservation, Hsp30 null cultures give lower final biomass yields [11].

Anatomical context of HSP30

  • HSP30, encoding the plasma membrane heat shock protein, is shown in this study to be activated by several stresses [12].

Associations of HSP30 with chemical compounds

  • Thus, the HSP26 and the HSP30 promoter can be used for late, phase-specific expression of the desired genes with glucose or maltose as carbon source, and HSP12 with glucose only [13].
  • They also have lower ATP levels, consistent with higher H(+)-ATPase activity, at the glucose exhaustion stage of batch fermentations (diauxic lag), when Hsp30 is normally induced [11].
  • This Hsp30 is induced by several stresses, including heat shock, ethanol exposure, severe osmostress, weak organic acid exposure and glucose limitation [11].

Other interactions of HSP30

  • HSP12, HSP26 and HSP30 were highly expressed [13].
  • In this study, we analyzed the in vivo binding of yeast heat shock factor (HSF) to the promoters of target genes ScSSA1, ScSSA4, HSP30 and HSP104, using chromatin immunoprecipitation [14].
  • The HSP30 promoter has no good agreement to the HSE consensus and its stress activation is unaffected by a mutation (hsf1-m3) that causes defective heat shock activation of Hsf1-dependent genes [12].
  • We refer to YDR033w as MRH1 to denote that it encodes a membrane protein related to Hsp30p [15].


  1. Induction of major heat-shock proteins of Saccharomyces cerevisiae, including plasma membrane Hsp30, by ethanol levels above a critical threshold. Piper, P.W., Talreja, K., Panaretou, B., Moradas-Ferreira, P., Byrne, K., Praekelt, U.M., Meacock, P., Récnacq, M., Boucherie, H. Microbiology (Reading, Engl.) (1994) [Pubmed]
  2. Action of BTN1, the yeast orthologue of the gene mutated in Batten disease. Pearce, D.A., Ferea, T., Nosel, S.A., Das, B., Sherman, F. Nat. Genet. (1999) [Pubmed]
  3. Global phenotypic analysis and transcriptional profiling defines the weak acid stress response regulon in Saccharomyces cerevisiae. Schüller, C., Mamnun, Y.M., Mollapour, M., Krapf, G., Schuster, M., Bauer, B.E., Piper, P.W., Kuchler, K. Mol. Biol. Cell (2004) [Pubmed]
  4. Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. Foury, F., Talibi, D. J. Biol. Chem. (2001) [Pubmed]
  5. Haa1, a protein homologous to the copper-regulated transcription factor Ace1, is a novel transcriptional activator. Keller, G., Ray, E., Brown, P.O., Winge, D.R. J. Biol. Chem. (2001) [Pubmed]
  6. The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis. Chattopadhyay, S., Muzaffar, N.E., Sherman, F., Pearce, D.A. J. Bacteriol. (2000) [Pubmed]
  7. Stationary-phase gene expression in Saccharomyces cerevisiae during wine fermentation. Riou, C., Nicaud, J.M., Barre, P., Gaillardin, C. Yeast (1997) [Pubmed]
  8. Sequence and analysis of 24 kb on chromosome II of Saccharomyces cerevisiae. Aljinovic, G., Pohl, T.M. Yeast (1995) [Pubmed]
  9. The C-terminus of yeast plasma membrane H+-ATPase is essential for the regulation of this enzyme by heat shock protein Hsp30, but not for stress activation. Braley, R., Piper, P.W. FEBS Lett. (1997) [Pubmed]
  10. The plasma membrane of yeast acquires a novel heat-shock protein (hsp30) and displays a decline in proton-pumping ATPase levels in response to both heat shock and the entry to stationary phase. Panaretou, B., Piper, P.W. Eur. J. Biochem. (1992) [Pubmed]
  11. Hsp30, the integral plasma membrane heat shock protein of Saccharomyces cerevisiae, is a stress-inducible regulator of plasma membrane H(+)-ATPase. Piper, P.W., Ortiz-Calderon, C., Holyoak, C., Coote, P., Cole, M. Cell Stress Chaperones (1997) [Pubmed]
  12. Stress induction of HSP30, the plasma membrane heat shock protein gene of Saccharomyces cerevisiae, appears not to use known stress-regulated transcription factors. Seymour, I.J., Piper, P.W. Microbiology (Reading, Engl.) (1999) [Pubmed]
  13. Phase-specific gene expression in Saccharomyces cerevisiae, using maltose as carbon source under oxygen-limiting conditions. Donalies, U.E., Stahl, U. Curr. Genet. (2001) [Pubmed]
  14. Effects of heat stress on yeast heat shock factor-promoter binding in vivo. Li, N., Zhang, L.M., Zhang, K.Q., Deng, J.S., Prandl, R., Schoffl, F. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
  15. Expression and subcellular localization of a membrane protein related to Hsp30p in Saccharomyces cerevisiae. Wu, K., Dawe, J.H., Aris, J.P. Biochim. Biophys. Acta (2000) [Pubmed]
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