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Gene Review:

MFT1 - Mft1p

Saccharomyces cerevisiae S288c

Synonyms: Mitochondrial fusion target protein 1, THO complex subunit MFT1, YML062C

Ouarzane, M. et al., Takakura, H. et al., Kho, C.J. et al., Garrett, J.M. et al., Li, L. et al., et al.

Ouarzane, Labbé, Péry,

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High impact information on MFT1

One of these yeast genes contains an unidentified open reading frame and the other, MFT1, is a gene isolated from a yeast mutant that fails to import a fusion protein into mitochondria [Garrett, J. M., Singh, K. K., Vonder Haar, R. A. & Emr, S. D. (1991) Mol. Gen. Genet. 225, 483-491] [1].
Measurement of mitochondrial iron in cells grown in iron-rich medium overexpressing MFT1 or MFT2 show a 2-5-fold increase in iron compared with mitochondria from control cells [2].
Finally, this analysis has provided the first sequence information available for several of the acetylated ribosomal proteins and for one non-acetylated ribosomal protein, which is clearly the product of the MFT1 gene (Garrett, J. M., Singh, K. K., Vonder Haar, R. A., and Emr. S. D. (1991) Mol. Gen. Gen. 225, 483-491) [3].
The expressions of mammalian fte-1, plant cyc-07 and yeast MFT1 have all been shown to be cell-cycle-regulated and involved in protein synthesis at the level of the ribosome [4].
Based upon amino acid sequence comparison, EtS3a is highly homologous to v-fos transformation effector (encoded by the fte-1 gene) and cyc-07 (a plant homologue of fte-1) and similar to the yeast MFT1 (encoded by the mitochondrial fusion targeting gene) [4].

Biological context of MFT1

The MFT1 gene is 91% identical to an open reading frame 3' of the SIR3 gene [5].
Yeast cells harboring mft1 mutations are compromised in mitochondrial protein targeting, and Mft1p has previously been identified as a ribosomal protein [6].

Other interactions of MFT1

Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene [5].

References

Fte-1, a v-fos transformation effector gene, encodes the mammalian homologue of a yeast gene involved in protein import into mitochondria. Kho, C.J., Zarbl, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
Characterization of two homologous yeast genes that encode mitochondrial iron transporters. Li, L., Kaplan, J. J. Biol. Chem. (1997) [Pubmed]
NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae. Takakura, H., Tsunasawa, S., Miyagi, M., Warner, J.R. J. Biol. Chem. (1992) [Pubmed]
Eimeria tenella: cloning and characterization of cDNA encoding a S3a ribosomal protein. Ouarzane, M., Labbé, M., Péry, P. Gene (1998) [Pubmed]
Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene. Garrett, J.M., Singh, K.K., Vonder Haar, R.A., Emr, S.D. Mol. Gen. Genet. (1991) [Pubmed]
The protein encoded by the MFT1 gene is a targeting factor for mitochondrial precursor proteins, and not a core ribosomal protein. Beilharz, T., Beddoe, T., Landl, K., Cartwright, P., Lithgow, T. FEBS Lett. (1997) [Pubmed]

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