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Gene Review:

HUG1 - Hug1p

Saccharomyces cerevisiae S288c

Synonyms: MEC1-mediated checkpoint protein HUG1, YML058W-A

Basrai, M.A. et al., Carter, C.D. et al.

Basrai, Velculescu, Kinzler, Hieter,

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Disease relevance of HUG1

Transcription of one of these, NORF5/HUG1 (hydroxyurea and UV and gamma radiation induced), is induced by DNA damage, and this induction requires MEC1, a homolog of the ataxia telangiectasia mutated (ATM) gene [1].

High impact information on HUG1

We also find that sod1Delta strains, and to a lesser extent lys7Delta strains, when arrested with hydroxyurea (HU) show reduced induction of the MEC1 pathway effector Rnr3p and of Hug1p [2].
DNA damage-specific induction of HUG1, which is independent of the cell cycle stage, is due to the alleviation of repression by the Crt1p-Ssn6p-Tup1p complex [1].
NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae [1].

References

NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae. Basrai, M.A., Velculescu, V.E., Kinzler, K.W., Hieter, P. Mol. Cell. Biol. (1999) [Pubmed]
Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors. Carter, C.D., Kitchen, L.E., Au, W.C., Babic, C.M., Basrai, M.A. Mol. Cell. Biol. (2005) [Pubmed]

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