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Gene Review:

VPS20 - ESCRT-III subunit protein VPS20

Saccharomyces cerevisiae S288c

Synonyms: ASI10, Amino acid sensor-independent protein 10, CHM6, Charged multivesicular body protein 6, ESCRT-III complex subunit VPS20, ...

Yeo, S.C. et al., Kranz, A. et al., Babst, M. et al., Teo, H. et al.

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High impact information on VPS20

Differential centrifugation experiments demonstrated that about half of the hydrophilic proteins Mos10 and Vps20 was membrane associated [1].
Deletion of either VPS20 (vps20Delta) or VTA1 (vta1Delta) leads to similar class E Vps- phenotypes resembling those of vps4Delta, including carboxypeptidase Y (CPY) secretion, a block in ubiquitin-dependent MVB sorting, and a delay in both post-internalisation endocytic transport and biosynthetic transport to the vacuole [2].
We propose that Vps20p and Vta1p regulate Vps4p function in vivo [2].
Vps25 is the chief subunit responsible for Vps20 recruitment [3].
The Vps20-Snf7 subcomplex binds to the endosomal membrane, in part via the myristoyl group of Vps20 [4].

Biological context of VPS20

Both ATP binding [Vps4p-(K179A)] and ATP hydrolysis [Vps4p-(E233Q)] mutant proteins exhibit enhanced binding to Vps20p and Vta1p in vitro [2].

References

A family of small coiled-coil-forming proteins functioning at the late endosome in yeast. Kranz, A., Kinner, A., Kölling, R. Mol. Biol. Cell (2001) [Pubmed]
Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. Yeo, S.C., Xu, L., Ren, J., Boulton, V.J., Wagle, M.D., Liu, C., Ren, G., Wong, P., Zahn, R., Sasajala, P., Yang, H., Piper, R.C., Munn, A.L. J. Cell. Sci. (2003) [Pubmed]
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Teo, H., Perisic, O., González, B., Williams, R.L. Dev. Cell (2004) [Pubmed]
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Babst, M., Katzmann, D.J., Estepa-Sabal, E.J., Meerloo, T., Emr, S.D. Dev. Cell (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AGOS_AGR014W	Ashbya gossypii ATCC 10895
LOC100147988	Danio rerio
KLLA0F09295g	Kluyveromyces lactis NRRL Y-1140
MGG_02515	Magnaporthe oryzae 70-15
vps20	Schizosaccharomyces pombe 972h-

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