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Gene Review:

TRS130 - Trs130p

Saccharomyces cerevisiae S288c

Synonyms: TRAPP II-specific subunit 130, Trafficking protein particle complex II-specific subunit 130, Transport protein particle 130 kDa subunit, YM8261.12C, YMR218C

Zhang, C.J. et al., Yamamoto, K. et al.

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High impact information on TRS130

Increasing the gene dosage of YPT31/32 also suppressed lethality resulting from deletion of TRS130 or TRS120 but not three other essential TRAPP subunit-encoding genes [1].
A genetic screen for synthetic lethal interactions with arf1(-) identified a recessive mutation in TRS130, one of 10 components in the trafficking protein particle (TRAPP) complex (Sacher et al., 2000) [1].
Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae [2].
YPT31 and YPT32, the multi-copy suppressors of the trs130(ts1) mutant, differed in the extent of suppression of the mutant phenotypes and in their genetic interaction with TRS130 [2].

Biological context of TRS130

As TRS130 is an essential gene, the synthetic lethal allele (trs130-101) is a novel one that requires ARF1 for viability [1].

Other interactions of TRS130

Genetic interactions link ARF1, YPT31/32 and TRS130 [1].

References

Genetic interactions link ARF1, YPT31/32 and TRS130. Zhang, C.J., Bowzard, J.B., Greene, M., Anido, A., Stearns, K., Kahn, R.A. Yeast (2002) [Pubmed]
Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae. Yamamoto, K., Jigami, Y. Curr. Genet. (2002) [Pubmed]

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AGOS_AER352C	Ashbya gossypii ATCC 10895
KLLA0C07128g	Kluyveromyces lactis NRRL Y-1140

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