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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MDG1  -  Mdg1p

Saccharomyces cerevisiae S288c

Synonyms: Multicopy suppressor of defective G-protein 1, N1673, Signal transduction protein MDG1, YNL173C
 
 
 
 
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Disease relevance of MDG1

  • Deletion of MDG1 causes sterility in cells in which the wild-type G beta has been replaced by partly defective G beta derivatives but does not cause any other obvious phenotypes [1].
 

High impact information on MDG1

  • The same genetic screen identified BEM1, which encodes an SH3 domain protein required for polarized morphogenesis in response to pheromone, and a novel gene, designated MDG1 (multicopy suppressor of defective G-protein) [1].
  • Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity [1].
  • A fusion of Mdg1p with the green fluorescent protein from Aequorea victoria localizes to the plasma membrane, suggesting that Mdg1p is an extrinsically bound membrane protein [1].

References

  1. Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity. Leberer, E., Chenevert, J., Leeuw, T., Harcus, D., Herskowitz, I., Thomas, D.Y. Mol. Gen. Genet. (1996) [Pubmed]
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