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Gene Review

TEP1  -  Tep1p

Saccharomyces cerevisiae S288c

Synonyms: N1220, N1872, YNL128W
 
 
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High impact information on TEP1

  • Yeast strains deleted for TEP1 exhibit essentially no phenotype in haploids; however, diploids exhibit resistance to the phosphatidylinositol-3-phosphate kinase inhibitor wortmannin and to lithium ions [1].
  • TEP1 RNA is present throughout the cell cycle, and levels are dramatically up-regulated during meiotic development [1].
  • Although rates of cancer increase with age, neither tep1 haploids nor diploids have altered life spans [1].
  • Although homozygous tep1 mutants initiate the meiotic program and form spores with wild-type kinetics, analysis of the spores produced in tep1 mutants indicates a specific defect in the trafficking or deposition of dityrosine, a major component of yeast spore walls, to the surface [1].
  • This effect depends on PI3K kinase activity and is reversed partially by a PI3K inhibitor (LY294002) and reversed fully by co-expression of catalytically active PTEN (but not its purported yeast orthologue, Tep1) [2].

References

  1. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Heymont, J., Berenfeld, L., Collins, J., Kaganovich, A., Maynes, B., Moulin, A., Ratskovskaya, I., Poon, P.P., Johnston, G.C., Kamenetsky, M., DeSilva, J., Sun, H., Petsko, G.A., Engebrecht, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Rodríguez-Escudero, I., Roelants, F.M., Thorner, J., Nombela, C., Molina, M., Cid, V.J. Biochem. J. (2005) [Pubmed]
 
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