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Gene Review

SFB2  -  COPII subunit SFB2

Saccharomyces cerevisiae S288c

Synonyms: ISS1, N2505, SEC24-related protein 2, SED5-binding protein 2, YNL049C, ...
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High impact information on SFB2


Biological context of SFB2

  • Overexpression of SFB2, a SEC24 homologue with 56% identity, partially suppressed not only the mutant phenotype of sec24-20 cells but also rescued the SEC24-disrupted cells [1].

Other interactions of SFB2

  • Sec24p and its two nonessential homologues Sfb2p and Sfb3p have been suggested to serve in cargo selection [4].


  1. Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum. Higashio, H., Kimata, Y., Kiriyama, T., Hirata, A., Kohno, K. J. Biol. Chem. (2000) [Pubmed]
  2. Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae. Kurihara, T., Hamamoto, S., Gimeno, R.E., Kaiser, C.A., Schekman, R., Yoshihisa, T. Mol. Biol. Cell (2000) [Pubmed]
  3. Evidence for overlapping and distinct functions in protein transport of coat protein Sec24p family members. Peng, R., De Antoni, A., Gallwitz, D. J. Biol. Chem. (2000) [Pubmed]
  4. Endoplasmic reticulum exit of a secretory glycoprotein in the absence of sec24p family proteins in yeast. Karhinen, L., Bastos, R.N., Jokitalo, E., Makarow, M. Traffic (2005) [Pubmed]
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