High impact information on SFB2

• In SEC24-disrupted cells rescued by overexpression of SFB2, some cargo proteins were still retained in the ER, while most of the protein transport was restored [1].
• Moreover, overexpression of ISS1 could suppress mutations in SEC22 [2].
• Moreover, the yeast two-hybrid assay revealed that Sfb2p, similarly to Sec24p, interacted with Sec23p [1].
• Whereas the deletion of SFB2 did not affect transport kinetics of various proteins, the maturation of the glycolipid-anchored plasma membrane protein Gas1p was differentially impaired in sfb3 knock-out cells [3].
• Sfb2p, a yeast protein related to Sec24p, can function as a constituent of COPII coats required for vesicle budding from the endoplasmic reticulum [1].

Biological context of SFB2

• Overexpression of SFB2, a SEC24 homologue with 56% identity, partially suppressed not only the mutant phenotype of sec24-20 cells but also rescued the SEC24-disrupted cells [1].

Other interactions of SFB2

• Sec24p and its two nonessential homologues Sfb2p and Sfb3p have been suggested to serve in cargo selection [4].

References