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Gene Review

CIN2  -  Cin2p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome instability protein 2, P1043, Tubulin-folding cofactor C, Tubulin-specific chaperone C, YPL241C
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High impact information on CIN2

  • In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes [1].
  • Interestingly, we found that a fraction of the T7-generated transcripts were 3' end processed and polyadenylated at or near the 3' ends of the hsp82 and the immediately downstream CIN2 genes [2].

Biological context of CIN2


Anatomical context of CIN2


  1. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Hoyt, M.A., Stearns, T., Botstein, D. Mol. Cell. Biol. (1990) [Pubmed]
  2. RNA polymerase-specific nucleosome disruption by transcription in vivo. Sathyanarayana, U.G., Freeman, L.A., Lee, M.S., Garrard, W.T. J. Biol. Chem. (1999) [Pubmed]
  3. Saccharomyces cerevisiae PAC2 functions with CIN1, 2 and 4 in a pathway leading to normal microtubule stability. Hoyt, M.A., Macke, J.P., Roberts, B.T., Geiser, J.R. Genetics (1997) [Pubmed]
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