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Gene Review:

CIN2 - Cin2p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome instability protein 2, P1043, Tubulin-folding cofactor C, Tubulin-specific chaperone C, YPL241C

Hoyt, M.A. et al., Sathyanarayana, U.G. et al., Hoyt, M.A. et al.

Hoyt, Macke, Roberts, Geiser,

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High impact information on CIN2

In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes [1].
Interestingly, we found that a fraction of the T7-generated transcripts were 3' end processed and polyadenylated at or near the 3' ends of the hsp82 and the immediately downstream CIN2 genes [2].

Biological context of CIN2

At 11 degrees C, cin mutants arrest at the mitosis stage of their cell cycle because of loss of most microtubule structure. cin1, cin2, and cin4 mutations also cause defects in two other microtubule-mediated processes, nuclear migration and nuclear fusion (karyogamy) [1].

Anatomical context of CIN2

The products of the Saccharomyces cerevisiae CIN1, CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function [3].

References

Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Hoyt, M.A., Stearns, T., Botstein, D. Mol. Cell. Biol. (1990) [Pubmed]
RNA polymerase-specific nucleosome disruption by transcription in vivo. Sathyanarayana, U.G., Freeman, L.A., Lee, M.S., Garrard, W.T. J. Biol. Chem. (1999) [Pubmed]
Saccharomyces cerevisiae PAC2 functions with CIN1, 2 and 4 in a pathway leading to normal microtubule stability. Hoyt, M.A., Macke, J.P., Roberts, B.T., Geiser, J.R. Genetics (1997) [Pubmed]

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AGOS_AFL149C	Ashbya gossypii ATCC 10895
KLLA0D12936g	Kluyveromyces lactis NRRL Y-1140

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