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Gene Review

CIN4  -  Arf family GTPase CIN4

Saccharomyces cerevisiae S288c

Synonyms: Chromosome instability protein 4, GTP-binding protein CIN4, GTP1, UGX1, YM9375.07, ...
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Disease relevance of CIN4

  • The latter gene product has homology to the E. coli gtp1 gene product, and may define a new family of putative GTP-binding proteins [1].

High impact information on CIN4

  • In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes [2].
  • Our findings suggest that the guanine nucleotide-binding Cin4p interacts with Cin1p and regulates its tubulin folding activity [3].
  • RIM11 maps near CIN4 on chromosome XIII [4].
  • The two genes are arranged head to head and share a 192 bp divergent promoter region that contains three TATAAA motives, two for the SNM1 and one for the UGX1 locus [5].
  • The second gene, UGX1, has an open reading frame of 573 bp coding for a polypeptide of 191 amino acid residues [5].

Biological context of CIN4


Regulatory relationships of CIN4


Other interactions of CIN4


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