Disease relevance of CIN4

• The latter gene product has homology to the E. coli gtp1 gene product, and may define a new family of putative GTP-binding proteins [1].

High impact information on CIN4

• In addition to mutations in the tubulin-encoding TUB genes, we found mutations in the CIN1, CIN2, and CIN4 genes [2].
• Our findings suggest that the guanine nucleotide-binding Cin4p interacts with Cin1p and regulates its tubulin folding activity [3].
• RIM11 maps near CIN4 on chromosome XIII [4].
• The two genes are arranged head to head and share a 192 bp divergent promoter region that contains three TATAAA motives, two for the SNM1 and one for the UGX1 locus [5].
• The second gene, UGX1, has an open reading frame of 573 bp coding for a polypeptide of 191 amino acid residues [5].

Biological context of CIN4

• The CIN1, CIN2 and CIN4 genes were cloned by complementation of the benomyl-supersensitive phenotype [6].
• DNA sequence analysis upstream of the yeast DNA repair gene SNM1 revealed gene GTP1 with an ORF of 573 bp on chromosome XIII [7].

Regulatory relationships of CIN4

• Gene disruption showed that GTP1 is not an essential gene and that it has no influence on the expression of the DNA repair gene SNM1 with which it shares a 191-bp promoter region [7].

Other interactions of CIN4

• REC114 is located on chromosome XIII approximately 4.9 cM from CIN4 [8].

References