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Gene Review

CUP9  -  Cup9p

Saccharomyces cerevisiae S288c

Synonyms: Homeobox protein CUP9, YPL177C
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Disease relevance of CUP9

  • An earlier study identified Cup9p as a protein required for an aspect of resistance to copper toxicity in S.cerevisiae [1].

High impact information on CUP9

  • These findings identify the physiological rationale for the targeting of Cup9 by Ubr1, and indicate that small compounds may regulate other ubiquitin-dependent pathways [2].
  • Cup9p acts as a repressor of PTR2, a gene encoding the transmembrane peptide transporter [1].
  • In contrast to engineered N-end rule substrates, which are recognized by Ubr1p through their destabilizing N-terminal residues, Cup9p is targeted by Ubr1p through an internal degradation signal [1].
  • Using an ethyl methanesulfonate mutant of a yeast strain in which CUP1 and ACE1 were deleted, we isolated a gene, designated CUP9, which permits yeast cells to grow at high concentrations of environmental copper, most notably when lactate is the sole carbon source [3].
  • CUP9 mRNA levels were, however, down regulated by copper when yeast cells were grown with glucose but not with lactate or glycerol-ethanol as the sole carbon source [3].

Other interactions of CUP9

  • Previous work demonstrated that dipeptides with destabilizing N-terminal residues allosterically activate UBR1, leading to accelerated in vivo degradation of CUP9 and the induction of PTR2 expression [4].
  • UBR1 targets CUP9 through its internal degron [5].


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