The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

RMI1  -  Rmi1p

Saccharomyces cerevisiae S288c

Synonyms: NCE4, RecQ-mediated genome instability protein 1, YPL024W
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on RMI1

  • Cells lacking RMI1 activate the Rad53 checkpoint kinase, undergo a mitotic delay, and display increased relocalization of the recombination repair protein Rad52, indicating the presence of spontaneous DNA damage [1].
  • Consistent with a role for RMI1 in maintaining genome integrity, rmi1Delta cells exhibit increased recombination frequency and increased frequency of gross chromosomal rearrangements [1].
  • We propose that the DNA binding specificity of Rmi1 plays a role in targeting Sgs1-Top3 to appropriate substrates [2].
  • We show that Rmi1 forms a heteromeric complex with Sgs1-Top3 in yeast and that these proteins interact directly in a recombinant system [2].
  • Biochemical studies demonstrate that recombinant Rmi1 is a structure-specific DNA binding protein with a preference for cruciform structures [2].
 

Regulatory relationships of RMI1

 

Other interactions of RMI1

  • In addition, rmi1Delta strains fail to fully activate Rad53 upon exposure to DNA-damaging agents, suggesting that Rmi1 is also an important part of the Rad53-dependent DNA damage response [1].

References

  1. RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. Chang, M., Bellaoui, M., Zhang, C., Desai, R., Morozov, P., Delgado-Cruzata, L., Rothstein, R., Freyer, G.A., Boone, C., Brown, G.W. EMBO J. (2005) [Pubmed]
  2. Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mullen, J.R., Nallaseth, F.S., Lan, Y.Q., Slagle, C.E., Brill, S.J. Mol. Cell. Biol. (2005) [Pubmed]
  3. Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion. Lai, M.S., Seki, M., Ui, A., Enomoto, T. EMBO Rep. (2007) [Pubmed]
 
WikiGenes - Universities